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Access through your institution Buy or subscribe The mechanisms that control the diversification of tissue-resident macrophages remain unclear. In _Science_, Geissmann and colleagues perform
spatio-temporal analysis of macrophage development in mice. Transcriptional profiling of embryonic erythro-myeloid progenitors, fetal CD45+Lin−c-kit− pre-macrophages and F4/80+ adult tissue
macrophages identifies a core macrophage transcriptional program, including expression of the transcription-factor-encoding genes _Csf1r_, _Maf_, _Batf3_, _Pparg_, _Irf8_ and _Zeb2_, that
is acquired in pre-macrophages as they colonize the embryo in a manner dependent on the chemokine receptor CX3CR1. Tissue-specific signatures are acquired in each population as early as
embryonic day 12.5 in microglia, Kupffer cells and kidney macrophages or undergo postnatal changes in Langerhans cells and alveolar macrophages. Genes encoding some tissue-specific factors
are expressed as early as embryonic day 10.26 in tissue macrophages (_Sall1_ and _Sall3_) or are expressed in erythro-myeloid progenitors or pre-macrophages (_Id1_ and _Sall3_) before their
expression becomes restricted to a certain macrophage subset. The transcription factor Id3 emerges as being important for the development and maintenance of Kupffer cells. _Science_ (4
August 2016) doi:10.1126/science.aaf4238 This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal
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Authors * Ioana Visan View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS
ARTICLE Visan, I. Macrophage core program. _Nat Immunol_ 17, 1141 (2016). https://doi.org/10.1038/ni.3569 Download citation * Published: 20 September 2016 * Issue Date: October 2016 * DOI:
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