Allogeneic hematopoietic cell transplantation for t-aml following liver transplantation from the same haploidentical donor

Allogeneic hematopoietic cell transplantation for t-aml following liver transplantation from the same haploidentical donor

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Access through your institution Buy or subscribe Continuous immunosuppressive treatment after solid organ transplantation is associated with an increased incidence of therapy-related AML


(t-AML).1 The prognosis of t-AML is poor and the treatment with the highest potential for cure is allogeneic hematopoietic cell transplantation (Allo-HCT).2, 3 We report the first case of


Allo-HCT for t-AML that developed after liver transplantation (LTX) from the identical donor. Currently, published reports include cases of sibling Allo-HCT after unrelated cadaveric LTX for


aplastic anemia,7 matched unrelated Allo-HCT after cadaveric LTX in a patient with hyperimmunoglobulin M syndrome,8 combined transplantation of BM and liver from a cadaveric donor for liver


cancer9 and Allo-HCT after orthotopic LTX for hemophagocytic lymphohistiocytosis.10 These cases differ significantly from ours as the underlying diseases did not develop after LTX. The


reported case indicates that haploidentical Allo-HCT as a treatment for t-AML developing under immunosuppression is feasible and can induce durable remission. However, opportunistic


infections have to be monitored carefully based on the profound immune defect in this situation. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access


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Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional


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PubMed  Google Scholar  Download references AUTHOR INFORMATION Author notes * R Zeiser and A Zerweck: These authors contributed equally to this work. AUTHORS AND AFFILIATIONS * Department


Division of Hematology and Oncology, of Medicine, Freiburg University Medical Center, Albert-Ludwigs-University, Freiburg, Germany R Zeiser, A Zerweck, H Bertz & J Finke Authors * R


Zeiser View author publications You can also search for this author inPubMed Google Scholar * A Zerweck View author publications You can also search for this author inPubMed Google Scholar *


H Bertz View author publications You can also search for this author inPubMed Google Scholar * J Finke View author publications You can also search for this author inPubMed Google Scholar


CORRESPONDING AUTHOR Correspondence to J Finke. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Zeiser, R., Zerweck, A., Bertz, H. _et al._ Allogeneic


hematopoietic cell transplantation for t-AML following liver transplantation from the same haploidentical donor. _Bone Marrow Transplant_ 43, 589–590 (2009).


https://doi.org/10.1038/bmt.2008.361 Download citation * Published: 03 November 2008 * Issue Date: April 2009 * DOI: https://doi.org/10.1038/bmt.2008.361 SHARE THIS ARTICLE Anyone you share


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