ABSTRACT We compared urinary levels of cytokines in patients with and without albuminuria, proteinuria and kidney disease (glomerular filtration rate<60 mL/min per 1.73 m2) after HCT.

Plasma and urine were collected at baseline and weekly through day 100 and monthly through year 1, for measurement of IL-6, gp130, sIL6r, IL-10, IL15, MCP-1 and urine albumin-to-creatinine

ratios (ACRs). Cox-proportional hazards modeling examined associations between urinary cytokine levels and development of these renal end points. The association of ACR with the hazard of

overall mortality was assessed using Cox regression. Increasing urinary IL-6 and IL-15 were associated with an increased risk of developing proteinuria. Urinary MCP-1 during the first 100

are associated with development of albuminuria and proteinuria, suggesting early intra-renal inflammation as an important pathogenetic mechanism. Albuminuria and proteinuria within the first

100 days post HCT are associated with decreased overall survival. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution

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about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS EARLY POSTOPERATIVE URINARY MCP-1 AS A POTENTIAL BIOMARKER PREDICTING

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survival. _Biol Blood Marrow Transplant_ 2008; 14: 1365–1372. Article  Google Scholar  Download references ACKNOWLEDGEMENTS This research was supported by the National Institutes of Health

(NIDDK) 1R01DK080860-01. Chronic kidney disease in survivors of hematopoietic cell transplant received by Dr Hingorani. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of

Pediatrics, Seattle Children’s Hospital/University of Washington, Seattle, WA, USA S Hingorani & E Pao * Fred Hutchinson Cancer Research Institute, Seattle, WA, USA T Gooley, B Sandmaier

 & G McDonald Authors * S Hingorani View author publications You can also search for this author inPubMed Google Scholar * T Gooley View author publications You can also search for this

author inPubMed Google Scholar * E Pao View author publications You can also search for this author inPubMed Google Scholar * B Sandmaier View author publications You can also search for

this author inPubMed Google Scholar * G McDonald View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to S Hingorani.

ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no conflict of interest. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hingorani, S.,

Gooley, T., Pao, E. _et al._ Urinary cytokines after HCT: evidence for renal inflammation in the pathogenesis of proteinuria and kidney disease. _Bone Marrow Transplant_ 49, 403–409 (2014).

https://doi.org/10.1038/bmt.2013.197 Download citation * Received: 18 August 2013 * Accepted: 22 October 2013 * Published: 09 December 2013 * Issue Date: March 2014 * DOI:

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currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * albuminuria * proteinuria * chronic kidney disease *

mortality * hematopoietic cell transplant