ABSTRACT Aberrant expression of Class II MHC antigens (la) by non-immune cells is considered to be an important mechanism in the pathogenesis of autoimmune disease processes including those

affecting the eye. It is suggested that circulating autoreactive T-cells are directed to their target organ as a result of aberrant expression of la antigens by the vascular endothelium of

that organ. This hypothesis was tested in this study using two different models of severe ocular inflammation, induced by either S-antigen or bovine serum albumin (BSA). The retinal vascular

endothelium becomes Ia+ in S-antigen induced inflammation but not in inflammation induced by BSA. The accumulation in the eye of a T-cell line, ThS, specific for an ocular antigen

These results suggest that when the retinal vascular endothelium expresses la antigens during an inflammatory process, autoreactive T-cells will be specifically retained in the eye as a

result of this and perpetuate the autoimmune destructive process. SIMILAR CONTENT BEING VIEWED BY OTHERS ANALYSIS OF PERIPHERAL INFLAMMATORY T CELL SUBSETS AND THEIR EFFECTOR FUNCTION IN

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IMMUNOPATHOLOGICAL MECHANISMS AND CLINICAL MANIFESTATIONS OF OCULAR GRAFT-VERSUS-HOST DISEASE FOLLOWING HEMATOPOIETIC STEM CELL TRANSPLANTATION Article 31 May 2024 ARTICLE PDF REFERENCES *

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mechanisms in autoimmune ocular disease. _Eye_ 2, 260–266 (1988). https://doi.org/10.1038/eye.1988.51 Download citation * Issue Date: 01 May 1988 * DOI: https://doi.org/10.1038/eye.1988.51

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