ABSTRACT We analyzed two West African samples (Guinea-Bissau: _n_=289 cases and 322 controls; The Gambia: _n_=240 cases and 248 controls) to evaluate single-nucleotide polymorphisms (SNPs)

in _Epiregulin_ (_EREG_) and V-ATPase (_T-cell immune regulator 1_ (_TCIRG1_)) using single and multilocus analyses to determine whether previously described associations with pulmonary

tuberculosis (PTB) in Vietnamese and Italians would replicate in African populations. We did not detect any significant single locus or haplotype associations in either sample. We also

performed exploratory pairwise interaction analyses using Visualization of Statistical Epistasis Networks (ViSEN), a novel method to detect only interactions among multiple variables, to

PTB susceptibility, to the extent that they exist, are dependent on gene–gene interactions in West African populations as detected with ViSEN. In addition, epistatic effects are likely to be

influenced by inter- and intra-population differences in genetic or environmental context and/or the mycobacterial lineages causing disease. Access through your institution Buy or subscribe

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OTHERS GENOME-WIDE HOST-PATHOGEN ANALYSES REVEAL GENETIC INTERACTION POINTS IN TUBERCULOSIS DISEASE Article Open access 01 February 2023 PAIRED ANALYSIS OF HOST AND PATHOGEN GENOMES

IDENTIFIES DETERMINANTS OF HUMAN TUBERCULOSIS Article Open access 29 November 2024 _SLC11A1_ GENETIC VARIATION AND LOW EXPRESSION MAY CAUSE IMMUNE RESPONSE IMPAIRMENT IN TB PATIENTS Article

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World Scientific Publishing, pp 315–326. Download references ACKNOWLEDGEMENTS This work was supported by the Medical Research Council (MRC UK) award G0000690 to GS and by grants from the

Danish Medical Research Council, the Danish Society of Respiratory Medicine and the Danish Council of Development Research to CW and LJØ. MJW and SMW were partially supported by NIH Grant

P20 GM103534. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Center for Human Genetics Research, Vanderbilt University, Nashville, TN, USA M J White * Department of Genetics and Institute of

Quantitative Biomedical Sciences, Dartmouth College, Hanover, NH, USA M J White, J S Chen, T Hu, J H Moore & S M Williams * Centro di Ricerca, Ospedale San Pietro Fatebenefratelli, Rome,

Italy A Tacconelli, G Novelli & G Sirugo * Bandim Health Project, Danish Epidemiology Science Centre and Statens Serum Institute, Bissau, Guinea-Bissau C Wejse & V F Gomes *

Department of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark C Wejse & L J Østergaard * Center for Global Health, School of Public Health, Aarhus University, Skejby,

Denmark C Wejse * Centre for International Health, University of Otago School of Medicine, Dunedin, New Zealand P C Hill * MRC Laboratories, Fajara, The Gambia P C Hill * Vanderbilt

Epidemiology Center, Vanderbilt University, Nashville, TN, USA D R Velez-Edwards * Institute for Medicine and Public Health, Vanderbilt University, Nashville, TN, USA D R Velez-Edwards *

Center for Human Genetics Research, Vanderbilt University, Nashville, TN, USA D R Velez-Edwards * Department of Obstetrics and Gynecology, Vanderbilt University, Nashville, TN, USA D R

Velez-Edwards * Dipartimento di Biomedicina e Prevenzione, Sezione di Genetica, Università di Roma ‘Tor Vergata’, Rome, Italy G Novelli * Dr John T. Macdonald Foundation Department of Human

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CORRESPONDING AUTHORS Correspondence to S M Williams or G Sirugo. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no conflict of interest. ADDITIONAL INFORMATION Supplementary

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PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE White, M., Tacconelli, A., Chen, J. _et al._ Epiregulin (_EREG_) and human V-ATPase (_TCIRG1_): genetic variation,

ethnicity and pulmonary tuberculosis susceptibility in Guinea-Bissau and The Gambia. _Genes Immun_ 15, 370–377 (2014). https://doi.org/10.1038/gene.2014.28 Download citation * Received: 14

January 2014 * Revised: 23 April 2014 * Accepted: 24 April 2014 * Published: 05 June 2014 * Issue Date: September 2014 * DOI: https://doi.org/10.1038/gene.2014.28 SHARE THIS ARTICLE Anyone

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