ABSTRACT AIM To investigate the role of the Chinese herbal medicine Xianhuayin on the reversal of 7,12‐dimethylbenz[a]anthracene (DMBA)‐induced premalignant mucosal lesions in the oral

buccal pouch of golden hamsters. METHODOLOGY The animals were randomly divided into a non‐diseased control group (_n_=5) and an experimental group including 50 animals in which the buccal

mucosa had been painted with DMBA (0.5% in acetone) to generate an oral mucosa premalignant lesion. Animals in the experimental group were further divided into Xianhuayin‐treated group

(_n_=30), untreated premalignant lesion group (_n_=10) and normal saline (NS)‐treated group (_n_=10). The cheek (buccal) pouch mucosa of the golden hamsters in each group was observed with

became distinct in the Xianhuayin‐treated group. Scanning electronic microscopic (SEM) analysis showed that surface of the cells exhibited honeycomb structures in the hamster of

untreated‐group. The cells were morphologically irregular, overlapped and loosened in the untreated premalignant lesion group. Most of the cell surface exhibited honeycomb structure in the

Xianhuayin‐treated group. Transmission electronic microscopic (TEM) analysis showed that buccal mucosal epithelial cells were morphologically regular in the non‐diseased control group.

Desmosomes and tonofibrils were reduced and the nucleus was morphologically irregular in the untreated premalignant lesion group. In the Xianhuayin‐treated group, the widening intercellular

gap was gradually reduced, desmosomes and the cells becoming morphologically regular. No significant difference was observed between the hamsters in NS‐treated group and those in the

untreated premalignant lesion group. Significant therapeutic efficacy was observed in the group receiving Xianhuayin. CONCLUSION Xianhuayin is effective in the reversal of DMBA‐induced

premalignant lesions in the buccal pouch of golden hamsters. You have full access to this article via your institution. Download PDF SIMILAR CONTENT BEING VIEWED BY OTHERS THE POTENTIAL

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ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Stomatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China Yan‐zhi Xu, Yong‐le Qiu, Zhi‐guang

An & Feng‐ying Yang Authors * Yan‐zhi Xu View author publications You can also search for this author inPubMed Google Scholar * Yong‐le Qiu View author publications You can also search

for this author inPubMed Google Scholar * Zhi‐guang An View author publications You can also search for this author inPubMed Google Scholar * Feng‐ying Yang View author publications You can

also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Yan‐zhi Xu. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE

Xu, Y., Qiu, Y., An, Z. _et al._ Role of the Chinese Herbal Medicine Xianhuayin on the Reversal of Premalignant Mucosal Lesions in the Golden Hamster Buccal Pouch. _Int J Oral Sci_ 2, 53–58

(2010). https://doi.org/10.4248/IJOS10013 Download citation * Received: 15 September 2009 * Revised: 12 November 2009 * Accepted: 12 November 2009 * Published: 01 March 2010 * Issue Date: 01

March 2010 * DOI: https://doi.org/10.4248/IJOS10013 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link

is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative KEYWORDS * Xianhuayin * oral premalignant lesion * golden

hamster * buccal pouch mucosa