ABSTRACT Sortilin1 (∼95 kDa) is a member of the recently discovered family of Vps10p-domain receptors2,3, and is expressed in a variety of tissues, notably brain, spinal cord and muscle. It

acts as a receptor for neurotensin4,5, but predominates in regions of the nervous system that neither synthesize nor respond to this neuropeptide6, suggesting that sortilin has additional

roles. Sortilin is expressed during embryogenesis7 in areas where nerve growth factor (NGF) and its precursor, proNGF, have well-characterized effects6,7. These neurotrophins can be released

by neuronal tissues8,9, and they regulate neuronal development through cell survival and cell death signalling. NGF regulates cell survival and cell death via binding to two different

sortilin acts as a co-receptor and molecular switch governing the p75NTR-mediated pro-apoptotic signal induced by proNGF. Access through your institution Buy or subscribe This is a preview

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P75NTR ACTIVATION: INTRINSICALLY MONOMERIC STATE OF DEATH DOMAINS INVOKES THE "HELPER" HYPOTHESIS Article Open access 13 August 2020 SURVIVAL OF COMPROMISED ADULT SENSORY NEURONS

INVOLVES MACROVESICULAR FORMATION Article Open access 24 November 2022 ANALYSIS OF THE EARLY RESPONSE TO SPINAL CORD INJURY IDENTIFIED A KEY ROLE FOR MTORC1 SIGNALING IN THE ACTIVATION OF

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(1998) CAS  PubMed  PubMed Central  Google Scholar  Download references ACKNOWLEDGEMENTS We thank M. V. Chao and G. R. Lewin for valuable discussions. J. Salzer, R. Kraemer and P. Fischer

are acknowledged for reagents and advice, and S. Tevar for assistance in p75NTR mice genotyping. This work was supported by the Novo Nordisk Foundation, The Danish Medical Research Council,

The Carlsberg Foundation (A.N. and C.M.P.) and the NIH (B.L.H. and R.L.). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Medical Biochemistry, Ole Worms Allé 170, Aarhus

University, Gustav Wieds vej 10, DK-8000, Aarhus C, Denmark Anders Nykjaer, Pernille Jansen, Peder Madsen, Morten S. Nielsen, Christian Jacobsen & Claus M. Petersen * ReceptIcon Aps,

Gustav Wieds vej 10, DK-8000, Aarhus C, Denmark Anders Nykjaer & Thomas E. Willnow * Weill Medical College of Cornell University, New York, 10021, New York, USA Ramee Lee, Kenneth K.

Teng & Barbara L. Hempstead * Max-Delbrück-Center for Molecular Medicine, 13125, Berlin, Germany Pernille Jansen & Thomas E. Willnow * Institute for Biotechnology,

Martin-Luther-Universität, Halle-Wittenberg, 06120, Halle, Germany Marco Kliemannel & Elisabeth Schwarz Authors * Anders Nykjaer View author publications You can also search for this

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search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Anders Nykjaer. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare that they have no competing

financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Nykjaer, A., Lee, R., Teng, K. _et al._ Sortilin is essential for proNGF-induced

neuronal cell death. _Nature_ 427, 843–848 (2004). https://doi.org/10.1038/nature02319 Download citation * Received: 03 November 2003 * Accepted: 23 December 2003 * Issue Date: 26 February

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