ABSTRACT Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma, and variability in IOP might herald glaucomatous development or progression. We report the

results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multi-ancestry participants

for IOP. We confirm genetic association of known loci for IOP and primary open-angle glaucoma (POAG) and identify four new IOP-associated loci located on chromosome 3q25.31 within the

_FNDC3B_ gene (_P_ = 4.19 × 10−8 for rs6445055), two on chromosome 9 (_P_ = 2.80 × 10−11 for rs2472493 near _ABCA1_ and _P_ = 6.39 × 10−11 for rs8176693 within _ABO_) and one on chromosome

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Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS GENOME-WIDE META-ANALYSIS IDENTIFIES 127 OPEN-ANGLE GLAUCOMA LOCI WITH CONSISTENT EFFECT ACROSS ANCESTRIES Article Open access

24 February 2021 LARGE-SCALE MULTITRAIT GENOME-WIDE ASSOCIATION ANALYSES IDENTIFY HUNDREDS OF GLAUCOMA RISK LOCI Article Open access 29 June 2023 WHOLE-EXOME SEQUENCING STUDY IDENTIFIES

RARE VARIANTS AND GENES ASSOCIATED WITH INTRAOCULAR PRESSURE AND GLAUCOMA Article Open access 30 November 2022 REFERENCES * Quigley, H.A. & Broman, A.T. The number of people with

glaucoma worldwide in 2010 and 2020. _Br. J. Ophthalmol._ 90, 262–267 (2006). CAS  PubMed  PubMed Central  Google Scholar  * Heijl, A., Leske, M.C., Bengtsson, B., Hyman, L. & Hussein,

M. Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial. _Arch. Ophthalmol._ 120, 1268–1279 (2002). Article  PubMed  Google Scholar  *

Collaborative Normal-Tension Glaucoma Study Group. The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma. Collaborative Normal-Tension Glaucoma

Study Group. _Am. J. Ophthalmol._ 126, 498–505 (1998). * Kass, M.A. et al. The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication

delays or prevents the onset of primary open-angle glaucoma. _Arch. Ophthalmol._ 120, 701–713 (2002). Article  PubMed  Google Scholar  * Wolfs, R.C. et al. Genetic risk of primary open-angle

glaucoma. Population-based familial aggregation study. _Arch. Ophthalmol._ 116, 1640–1645 (1998). Article  CAS  PubMed  Google Scholar  * Sanfilippo, P.G., Hewitt, A.W., Hammond, C.J. &

Mackey, D.A. The heritability of ocular traits. _Surv. Ophthalmol._ 55, 561–583 (2010). Article  PubMed  Google Scholar  * Burdon, K.P. et al. Genome-wide association study identifies

susceptibility loci for open angle glaucoma at _TMCO1_ and _CDKN2B_-_AS1_. _Nat. Genet._ 43, 574–578 (2011). Article  CAS  PubMed  Google Scholar  * van Koolwijk, L.M. et al. Common genetic

determinants of intraocular pressure and primary open-angle glaucoma. _PLoS Genet._ 8, e1002611 (2012). Article  CAS  PubMed  PubMed Central  Google Scholar  * Shah, S. et al. Relationship

between corneal thickness and measured intraocular pressure in a general ophthalmology clinic. _Ophthalmology_ 106, 2154–2160 (1999). Article  CAS  PubMed  Google Scholar  * Devlin, B. &

Roeder, K. Genomic control for association studies. _Biometrics_ 55, 997–1004 (1999). Article  CAS  PubMed  Google Scholar  * Higgins, J.P. & Thompson, S.G. Quantifying heterogeneity in

a meta-analysis. _Stat. Med._ 21, 1539–1558 (2002). Article  PubMed  Google Scholar  * Dudbridge, F. & Gusnanto, A. Estimation of significance thresholds for genomewide association

scans. _Genet. Epidemiol._ 32, 227–234 (2008). Article  PubMed  PubMed Central  Google Scholar  * Thorleifsson, G. et al. Common variants near _CAV1_ and _CAV2_ are associated with primary

open-angle glaucoma. _Nat. Genet._ 42, 906–909 (2010). Article  CAS  PubMed  PubMed Central  Google Scholar  * Ozel, A.B. et al. Genome-wide association study and meta-analysis of

intraocular pressure. _Hum. Genet._ 133, 41–57 (2014). Article  CAS  PubMed  Google Scholar  * Do, R. et al. Common variants associated with plasma triglycerides and risk for coronary artery

disease. _Nat. Genet._ 45, 1345–1352 (2013). Article  CAS  PubMed  PubMed Central  Google Scholar  * Grundberg, E. et al. Mapping _cis_- and _trans_-regulatory effects across multiple

tissues in twins. _Nat. Genet._ 44, 1084–1089 (2012). Article  CAS  PubMed  PubMed Central  Google Scholar  * Moayyeri, A., Hammond, C.J., Hart, D.J. & Spector, T.D. The UK Adult Twin

Registry (TwinsUK Resource). _Twin Res. Hum. Genet._ 16, 144–149 (2013). Article  PubMed  Google Scholar  * Hofman, A. et al. The Rotterdam Study: 2012 objectives and design update. _Eur. J.

Epidemiol._ 26, 657–686 (2011). Article  PubMed  PubMed Central  Google Scholar  * Lu, Y. et al. Genome-wide association analyses identify multiple loci associated with central corneal

thickness and keratoconus. _Nat. Genet._ 45, 155–163 (2013). Article  CAS  PubMed  PubMed Central  Google Scholar  * Tonnu, P.A. et al. The influence of central corneal thickness and age on

intraocular pressure measured by pneumotonometry, non-contact tonometry, the Tono-Pen XL, and Goldmann applanation tonometry. _Br. J. Ophthalmol._ 89, 851–854 (2005). Article  PubMed  PubMed

Central  Google Scholar  * Denis, M. et al. Expression, regulation, and activity of ABCA1 in human cell lines. _Mol. Genet. Metab._ 78, 265–274 (2003). Article  CAS  PubMed  Google Scholar

  * Yeghiazaryan, K. et al. An enhanced expression of ABC 1 transporter in circulating leukocytes as a potential molecular marker for the diagnostics of glaucoma. _Amino Acids_ 28, 207–211

(2005). Article  CAS  PubMed  Google Scholar  * Denomme, G.A. et al. Consortium for Blood Group Genes (CBGG): 2009 report. _Immunohematology_ 26, 47–50 (2010). CAS  PubMed  Google Scholar  *

Khan, M.I. et al. Association of ABO blood groups with glaucoma in the Pakistani population. _Can. J. Ophthalmol._ 44, 582–586 (2009). Article  PubMed  Google Scholar  * Janssen, S.F. et

al. Gene expression and functional annotation of the human ciliary body epithelia. _PLoS ONE_ 7, e44973 (2012). Article  CAS  PubMed  PubMed Central  Google Scholar  * Charlesworth, J. et

al. The path to open-angle glaucoma gene discovery: endophenotypic status of intraocular pressure, cup-to-disc ratio, and central corneal thickness. _Invest. Ophthalmol. Vis. Sci._ 51,

3509–3514 (2010). Article  PubMed  PubMed Central  Google Scholar  * Purcell, S.M. et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. _Nature_ 460,

748–752 (2009). Article  CAS  PubMed  Google Scholar  * Carbonaro, F., Andrew, T., Mackey, D.A., Spector, T.D. & Hammond, C.J. Comparison of three methods of intraocular pressure

measurement and their relation to central corneal thickness. _Eye (Lond.)_ 24, 1165–1170 (2010). Article  CAS  Google Scholar  * Mitchell, P., Smith, W., Attebo, K. & Wang, J.J.

Prevalence of age-related maculopathy in Australia. The Blue Mountains Eye Study. _Ophthalmology_ 102, 1450–1460 (1995). Article  CAS  PubMed  Google Scholar  * Foran, S., Wang, J.J. &

Mitchell, P. Causes of visual impairment in two older population cross-sections: the Blue Mountains Eye Study. _Ophthalmic Epidemiol._ 10, 215–225 (2003). Article  PubMed  Google Scholar  *

Aulchenko, Y.S. et al. Linkage disequilibrium in young genetically isolated Dutch population. _Eur. J. Hum. Genet._ 12, 527–534 (2004). Article  CAS  PubMed  Google Scholar  * Pardo, L.M.,

MacKay, I., Oostra, B., van Duijn, C.M. & Aulchenko, Y.S. The effect of genetic drift in a young genetically isolated population. _Ann. Hum. Genet._ 69, 288–295 (2005). Article  CAS 

PubMed  Google Scholar  * Leibowitz, H.M. et al. The Framingham Eye Study monograph: an ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular

degeneration, and visual acuity in a general population of 2631 adults, 1973–1975. _Surv. Ophthalmol._ 24, 335–610 (1980). Article  CAS  PubMed  Google Scholar  * Vitart, V. et al. New loci

associated with central cornea thickness include _COL5A1_, _AKAP13_ and _AVGR8_. _Hum. Mol. Genet._ 19, 4304–4311 (2010). Article  CAS  PubMed  Google Scholar  * Evans, S., Newnham, J.,

MacDonald, W. & Hall, C. Characterisation of the possible effect on birthweight following frequent prenatal ultrasound examinations. _Early Hum. Dev._ 45, 203–214 (1996). Article  CAS 

PubMed  Google Scholar  * Newnham, J.P., Evans, S.F., Michael, C.A., Stanley, F.J. & Landau, L.I. Effects of frequent ultrasound during pregnancy: a randomised controlled trial. _Lancet_

342, 887–891 (1993). Article  CAS  PubMed  Google Scholar  * Williams, L.A., Evans, S.F. & Newnham, J.P. Prospective cohort study of factors influencing the relative weights of the

placenta and the newborn infant. _Br. Med. J._ 314, 1864–1868 (1997). Article  CAS  Google Scholar  * Hofman, A. et al. The Rotterdam Study: 2014 objectives and design update. _Eur. J.

Epidemiol._ 28, 889–926 (2013). Article  CAS  PubMed  Google Scholar  * Mackey, D.A. et al. Twins eye study in Tasmania (TEST): rationale and methodology to recruit and examine twins. _Twin

Res. Hum. Genet._ 12, 441–454 (2009). Article  PubMed  Google Scholar  * Spector, T.D. & Williams, F.M. The UK Adult Twin Registry (TwinsUK). _Twin Res. Hum. Genet._ 9, 899–906 (2006).

Article  PubMed  Google Scholar  * Wang, Y.X., Xu, L., Yang, H. & Jonas, J.B. Prevalence of glaucoma in North China: the Beijing Eye Study. _Am. J. Ophthalmol._ 150, 917–924 (2010).

Article  PubMed  Google Scholar  * Lavanya, R. et al. Methodology of the Singapore Indian Chinese Cohort (SICC) eye study: quantifying ethnic variations in the epidemiology of eye diseases

in Asians. _Ophthalmic Epidemiol._ 16, 325–336 (2009). Article  PubMed  Google Scholar  * Foong, A.W. et al. Rationale and methodology for a population-based study of eye diseases in Malay

people: the Singapore Malay eye study (SiMES). _Ophthalmic Epidemiol._ 14, 25–35 (2007). Article  PubMed  Google Scholar  * Marchini, J., Howie, B., Myers, S., McVean, G. & Donnelly, P.

A new multipoint method for genome-wide association studies by imputation of genotypes. _Nat. Genet._ 39, 906–913 (2007). Article  CAS  PubMed  Google Scholar  * Howie, B.N., Donnelly, P.

& Marchini, J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. _PLoS Genet._ 5, e1000529 (2009). Article  PubMed  PubMed

Central  Google Scholar  * Li, Y., Willer, C.J., Ding, J., Scheet, P. & Abecasis, G.R. MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. _Genet.

Epidemiol._ 34, 816–834 (2010). Article  PubMed  PubMed Central  Google Scholar  * van der Valk, R. et al. Intraocular pressure–lowering effects of all commonly used glaucoma drugs: a

meta-analysis of randomized clinical trials. _Ophthalmology_ 112, 1177–1185 (2005). Article  PubMed  Google Scholar  * Stephens, M. & Balding, D.J. Bayesian statistical methods for

genetic association studies. _Nat. Rev. Genet._ 10, 681–690 (2009). Article  CAS  PubMed  Google Scholar  * Higgins, J.P., Thompson, S.G., Deeks, J.J. & Altman, D.G. Measuring

inconsistency in meta-analyses. _Br. Med. J._ 327, 557–560 (2003). Article  Google Scholar  * Liu, J.Z. et al. A versatile gene-based test for genome-wide association studies. _Am. J. Hum.

Genet._ 87, 139–145 (2010). Article  CAS  PubMed  PubMed Central  Google Scholar  * Nagelkerke, N.J.D. A note on a general definition of the coefficient of determination. _Biometrika_ 78,

691–692 (1991). Article  Google Scholar  * Rozen, S. & Skaletsky, H. Primer3 on the WWW for general users and for biologist programmers. _Methods Mol. Biol._ 132, 365–386 (2000). CAS 

PubMed  Google Scholar  Download references ACKNOWLEDGEMENTS We gratefully acknowledge the contributions of all participants who volunteered within each cohort and the personnel responsible

for the recruitment and administration of each study. We also thank the various funding sources that made this work possible. Complete funding information and acknowledgments can be found in

the Supplementary Note. AUTHOR INFORMATION Author notes * Pirro G Hysi, Ching-Yu Cheng, Henriët Springelkamp, Stuart Macgregor, Jessica N Cooke Bailey, Robert Wojciechowski and Ananth

Viswanathan: These authors contributed equally to this work. * Ananth Viswanathan, David A Mackey, Jamie E Craig, Janey L Wiggs, Cornelia M van Duijn, Christopher J Hammond and Tin Aung:

These authors jointly directed this work. AUTHORS AND AFFILIATIONS * Department of Twin Research and Genetic Epidemiology, King's College London, London, UK Pirro G Hysi, Abhishek Nag, 

Cristina Venturini, Timothy D Spector, Kerrin S Small & Christopher J Hammond * Singapore Eye Research Institute, Singapore National Eye Centre, Singapore Ching-Yu Cheng, Eranga Vithana,

 Jiemin Liao, Yingfeng Zheng, Seang-Mei Saw, Tien-Yin Wong & Tin Aung * Department of Ophthalmology, National University of Singapore and National University Health System, Singapore

Ching-Yu Cheng, Eranga Vithana, Chiea-Chuen Khor, Jiemin Liao, Seang-Mei Saw, Tien-Yin Wong & Tin Aung * Saw Swee Hock School of Public Health, National University of Singapore and

National University Health System, Singapore Ching-Yu Cheng, Yik-Ying Teo, Yingfeng Zheng, E-Shyong Tai, Seang-Mei Saw & Tien-Yin Wong * Duke–National University of Singapore Graduate

Medical School, Singapore Ching-Yu Cheng, Eranga Vithana, E-Shyong Tai & Seang-Mei Saw * Department of Ophthalmology, Erasmus Medical Center, Rotterdam, the Netherlands Henriët

Springelkamp, Wishal D Ramdas, Julia E Richards, Dominiek D G Despriet, Johannes R Vingerling, Roger C W Wolfs & Caroline C W Klaver * Department of Epidemiology, Erasmus Medical Center,

Rotterdam, the Netherlands Henriët Springelkamp, Wishal D Ramdas, Najaf Amin, Lennart C Karssen, Adriana I Iglesias, Elisabeth M van Leeuwen, Leonieke M E van Koolwijk, Fernando

Rivadeneira, André G Uitterlinden, Albert Hofman, Johannes R Vingerling, Caroline C W Klaver & Cornelia M van Duijn * Statistical Genetics, QIMR Berghofer Medical Research Institute

Royal Brisbane Hospital, Brisbane, Queensland, Australia Stuart Macgregor & Gabriel Cuellar-Partida * Department of Epidemiology and Biostatistics, Case Western Reserve University,

Cleveland, Ohio, USA Jessica N Cooke Bailey & Jonathan L Haines * Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA Robert

Wojciechowski * National Human Genome Research Institute, US National Institutes of Health, Baltimore, Maryland, USA Robert Wojciechowski, Claire L Simpson & Joan E Bailey-Wilson *

Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK Veronique Vitart * Centre for Eye Research Australia,

University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia Alex W Hewitt, Sandra E Staffieri, Lisa Kearns & David A Mackey * Department of

Ophthalmology, University Medical Center Mainz, Mainz, Germany René Höhn, Alireza Mirshahi & Norbert Pfeiffer * Institute of Ophthalmology, University College London, London, UK Cristina

Venturini * deCODE/Amgen, Reykjavik, Iceland Gudmar Thorleifsson, Unnur Thorsteinsdottir & Kari Stefansson * Division of Human Genetics, Genome Institute of Singapore, Singapore

Chiea-Chuen Khor * Eye Clinic, Reykjavik, Iceland Arni B Stefansson * Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China Ya

Xing Wang & Liang Xu * Department of Internal Medicine II, University Medical Center Mainz, Mainz, Germany Philipp S Wild * Department of Human Genetics, University of Michigan, Ann

Arbor, Michigan, USA Ayse B Ozel & Jun Z Li * National Health Service (NHS) Princess Alexandra Eye Pavilion, Edinburgh, UK Brian W Fleck * Clinic for General and Interventional

Cardiology, University Heart Center Hamburg, Hamburg, Germany Tanja Zeller * Department of Statistics and Applied Probability, National University of Singapore, Singapore Yik-Ying Teo * Duke

Eye Center, Duke University, Durham, North Carolina, USA Xiaoyan Luo & Terri L Young * Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA R Rand

Allingham & Michael A Hauser * Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Lübeck, Germany Andrea Senft * INSERM, UMR 774, Lille, France Céline

Bellenguez & Philippe Amouyel * Université Lille 2, Lille, France Céline Bellenguez & Philippe Amouyel * Institut Pasteur de Lille, Lille, France Céline Bellenguez & Philippe

Amouyel * Centre for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, UK James F Wilson * Channing Division of Network Medicine, Harvard Medical School, Boston,

Massachusetts, USA Jae H Kang & Louis R Pasquale * Department of Ophthalmology, Landspitali National University Hospital, Reykjavik, Iceland Vesteinn Jonsson * Human Genetics and

Genomic Medicine, Faulty of Medicine, University of Southampton, Southampton, UK Sarah Ennis * Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan,

USA Sayoko E Moroi * Genetic Epidemiology, QIMR Berghofer Medical Research Institute Royal Brisbane Hospital, Brisbane, Queensland, Australia Nicholas G Martin * Department of Ophthalmology,

University Medical Center Groningen, Groningen, the Netherlands Nomdo M Jansonius * Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth,

Western Australia, Australia Seyhan Yazar & David A Mackey * Department of Medicine, National University of Singapore and National University Health System, Singapore E-Shyong Tai *

Centre Hospitalier Régional Universitaire de Lille, Lille, France Philippe Amouyel * Department of Ophthalmology, Portsmouth Hospitals NHS Trust, Portsmouth, UK James Kirwan * Department of

Medicine, Duke University Medical Center, Durham, North Carolina, USA Michael A Hauser * Faculty of Medicine, University of Iceland, Reykjavik, Iceland Fridbert Jonasson * The University of

Queensland Diamantina Institute, Woollongabba, Queensland, Australia Paul Leo * Department of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston,

Massachusetts, USA Stephanie J Loomis, Louis R Pasquale & Janey L Wiggs * Department of Ophthalmology, Flinders University, Adelaide, South Australia, Australia Rhys Fogarty, Kathryn P

Burdon & Jamie E Craig * Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands Fernando Rivadeneira & André G Uitterlinden * Netherlands Consortium for

Healthy Ageing, Netherlands Genomics Initiative, The Hague, the Netherlands Fernando Rivadeneira, André G Uitterlinden & Albert Hofman * Institute of Clinical Chemistry and Laboratory

Medicine, Mainz, Germany Karl J Lackner * Netherlands Institute for Neuroscience, Amsterdam, the Netherlands Paulus T V M de Jong * Department of Ophthalmology, Leiden University Medical

Center, Leiden, the Netherlands Paulus T V M de Jong * Department of Ophthalmology, Academic Medical Center, Amsterdam, the Netherlands Paulus T V M de Jong * School of Women's and

Infants' Health, University of Western Australia, Perth, Western Australia, Australia Craig E Pennell * Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, the

Netherlands Ben A Oostra * Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK Andrew J Lotery * Université Bordeaux, ISPED (Institut de Santé

Publique, d'Epidémiologie et de Développement), Bordeaux, France Cécilia Maubaret & Cécile Delcourt * INSERM, Centre INSERM U897 Epidemiologie-Biostatistique Bordeaux, Bordeaux,

France Cécilia Maubaret & Cécile Delcourt * Glaucoma Service, Rotterdam Eye Hospital, Rotterdam, the Netherlands Hans G Lemij * National Institute for Health Research (NIHR) Biomedical

Research Centre, Moorfields Eye Hospital NHS Foundation Trust and University College London Institute of Ophthalmology, London, UK Ananth Viswanathan Authors * Pirro G Hysi View author

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CONSORTIA BMES GWAS GROUP NEIGHBORHOOD CONSORTIUM WELLCOME TRUST CASE CONTROL CONSORTIUM 2 CONTRIBUTIONS P.G.H., C.-Y.C., H.S., S.M., J.N.C.B. and R.W. performed analyses and drafted the

manuscript. S.M., A.J.L., J.E.B.-W., V.V., L.R.P., N.P., C.D., A.V., D.A.M., J.E.C., J.L.W., C.M.v.D., C.J.H. and T.A. jointly conceived the project and supervised the work. P.G.H., H.S.,

R.W., A.N., A.W.H., A.M., C.V., R.H., G.T., B.A.O., S.-M.S., W.D.R., E.V., C.-C.K., D.D.G.D., J.L., J.L.H., Y.X.W., F.R., P.S.W., H.G.L., A.B.O., J.Z.L., B.W.F., R.C.W.W., T.Z., S.E.S.,

Y.-Y.T., G.C.-P., X.L., R.R.A., J.E.R., A.S., Y.Z., C.B., A.I.I., L.X., J.F.W., J.H.K., L.C.K., K.S., V.J., A.G.U., N.M.J., U.T., J.R.V., N.A., S.E., S.E.M., N.G.M., S.Y., E.-S.T., E.M.v.L.,

P.A., J.K., M.A.H., F.J., P.L., A.H., S.J.L., R.F., L.K., P.T.V.M.d.J., K.J.L., C.L.S., C.E.P., L.M.E.v.K., C.M., C.C.W.K., K.P.B., T.D.S., T.-Y.W., D.A.M., J.E.C. and A.B.S. were

responsible for cohort-specific activities, data generation and analyses. T.L.Y. and K.S.S. were responsible for expression and eQTL work. P.G.H., C.-Y.C., H.S., S.M., T.-Y.W., D.A.M.,

J.L.W., C.M.v.D. and C.J.H. critically reviewed the manuscript. CORRESPONDING AUTHORS Correspondence to Christopher J Hammond or Tin Aung. ETHICS DECLARATIONS COMPETING INTERESTS The authors

declare competing financial interests. G.T., K.S. and U.T. are employees of deCODE Genetics/Amgen. C.D. has a consultant role for Laboratoires Théa, Novartis, Bausch+Lomb. ADDITIONAL

INFORMATION A full list of members appears in the Supplementary Note. A full list of members appears in the Supplementary Note. A full list of members appears in the Supplementary Note.

SUPPLEMENTARY INFORMATION SUPPLEMENTARY TEXT AND FIGURES Supplementary Tables 1–10, Supplementary Figure 1–3 and Supplementary Note. (PDF 3337 kb) RIGHTS AND PERMISSIONS Reprints and

permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Hysi, P., Cheng, CY., Springelkamp, H. _et al._ Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular

pressure and susceptibility to glaucoma. _Nat Genet_ 46, 1126–1130 (2014). https://doi.org/10.1038/ng.3087 Download citation * Received: 26 September 2013 * Accepted: 07 August 2014 *

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