ABSTRACT Hepatic natural killer (NK) cells mediate antigen-specific contact hypersensitivity (CHS) in mice deficient in T cells and B cells. We report here that hepatic NK cells, but not

splenic or naive NK cells, also developed specific memory of vaccines containing antigens from influenza, vesicular stomatitis virus (VSV) or human immunodeficiency virus type 1 (HIV-1).

Adoptive transfer of virus-sensitized NK cells into naive recipient mice enhanced the survival of the mice after lethal challenge with the sensitizing virus but not after lethal challenge

with a different virus. NK cell memory of haptens and viruses depended on CXCR6, a chemokine receptor on hepatic NK cells that was required for the persistence of memory NK cells but not for

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technical support and A. Wagers (Harvard Medical School) for Act(EGFP) mice. Supported by the US National Institutes of Health (AI069259, AI072252, AI078897, HL56949 and AR42689), the Ragon

Institute (U.H.v.A.), the Cancer Research Institute (S.P.) and the Ragon Institute of MIT, Harvard and MGH (S.P.). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pathology,

Harvard Medical School, Boston, Massachusetts, USA Silke Paust, Michael P Flynn, E Ashley Moseman, Balimkiz Senman & Ulrich H von Andrian * The Ragon Institute of MIT, MGH and Harvard,

Charlestown, Massachusetts, USA Silke Paust & Amalio Telenti * Department of Microbiology & Immunology and Emory Vaccine Center, Emory University, Atlanta, Georgia, USA Harvinder S

Gill, Bao-Zhong Wang & Richard W Compans * Department of Chemical Engineering, Texas Tech University, Lubbock, Texas, USA Harvinder S Gill * Department of Human Developmental Biology,

Jagiellonian University College of Medicine, Kraków, Poland Marian Szczepanik * Institute of Microbiology, University Hospital, University of Lausanne, Lausanne, Switzerland Amalio Telenti *

Department of Medicine, Yale Medical School, New Haven, Connecticut, USA Marian Szczepanik & Philip W Askenase * Immune Disease Institute, Boston, Massachusetts, USA Ulrich H von

Andrian Authors * Silke Paust View author publications You can also search for this author inPubMed Google Scholar * Harvinder S Gill View author publications You can also search for this

author inPubMed Google Scholar * Bao-Zhong Wang View author publications You can also search for this author inPubMed Google Scholar * Michael P Flynn View author publications You can also

search for this author inPubMed Google Scholar * E Ashley Moseman View author publications You can also search for this author inPubMed Google Scholar * Balimkiz Senman View author

publications You can also search for this author inPubMed Google Scholar * Marian Szczepanik View author publications You can also search for this author inPubMed Google Scholar * Amalio

Telenti View author publications You can also search for this author inPubMed Google Scholar * Philip W Askenase View author publications You can also search for this author inPubMed Google

Scholar * Richard W Compans View author publications You can also search for this author inPubMed Google Scholar * Ulrich H von Andrian View author publications You can also search for this

author inPubMed Google Scholar CONTRIBUTIONS S.P. and U.H.v.A. designed the study; S.P., H.S.G., B.Z.W. and M.F. did experiments; S.P., A.T. and B.S. collected and analyzed data; E.A.M.,

H.S.G., B.Z.W. and R.H.C. provided reagents; E.A.M., M.S. and P.W.A. provided technical support and conceptual advice; and S.P. and U.H.v.A. wrote the manuscript. CORRESPONDING AUTHOR

Correspondence to Ulrich H von Andrian. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial interests. SUPPLEMENTARY INFORMATION SUPPLEMENTARY TEXT AND FIGURES

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chemokine receptor CXCR6 in NK cell–mediated antigen-specific memory of haptens and viruses. _Nat Immunol_ 11, 1127–1135 (2010). https://doi.org/10.1038/ni.1953 Download citation * Received:

26 May 2010 * Accepted: 28 September 2010 * Published: 24 October 2010 * Issue Date: December 2010 * DOI: https://doi.org/10.1038/ni.1953 SHARE THIS ARTICLE Anyone you share the following

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