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ABSTRACT Understanding spatiotemporal complexity1,2,3 is important to many disciplines, from biology4,5 to finance6. However, because it is seldom possible to achieve complete control over
the parameters that determine the behaviour of real complex systems, it has been difficult to study such behaviour experimentally. Here we demonstrate a simple microfluidic bubble generator
that shows stable oscillatory patterns (both in space and time) of unanticipated complexity and uniquely long repetition periods. At low flow rates, the device produces a regular stream of
bubbles of uniform size. As the flow increases, the system shows intricate dynamic behaviour typified by a stable limit cycle of order 29 bubbles per period, which repeats without change
over intervals of up to 100 periods and more. As well as providing an example of a well-characterized and experimentally tractable model system with which to study complex, nonlinear
dynamics, such behaviour demonstrates that it is possible to observe complex and stable limit cycles without active external control. Access through your institution Buy or subscribe This is
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UNPREDICTABLE NATURE OF BUBBLE EVOLUTION Article Open access 01 December 2022 GALLOPING BUBBLES Article Open access 12 February 2025 UNIFIED FRAMEWORK FOR LASER-INDUCED TRANSIENT BUBBLE
DYNAMICS WITHIN MICROCHANNELS Article Open access 13 August 2024 REFERENCES * Schuster, H. G. _Deterministic Chaos: An Introduction_ (Wiley-VCH, Weinheim, 2003). MATH Google Scholar *
Cross, M. C. & Hohenberg, P. C. Pattern-formation outside of equilibrium. _Rev. Mod. Phys._ 65, 851–1112 (1993). Article ADS Google Scholar * Aranson, I. S. & Kramer, L. The world
of the complex Ginzburg-Landau equation. _Rev. Mod. Phys._ 74, 99–143 (2002). Article ADS MathSciNet Google Scholar * Stelling, J., Klamt, S., Bettenbrock, K., Schuster, S. &
Gilles, E. D. Metabolic network structure determines key aspects of functionality and regulation. _Nature_ 420, 190–193 (2002). Article ADS Google Scholar * Turing, A. M. The chemical
basis of morphogenesis. _Phil. Trans. R. Soc. Lond. B_ 237, 37–72 (1952). Article ADS MathSciNet Google Scholar * Gabaix, X., Gopikrishnan, P., Plerou, V. & Stanley, H. E. A theory
of power-law distributions in financial market fluctuations. _Nature_ 423, 267–270 (2003). Article ADS Google Scholar * Gollub, J. P. & Cross, M. C. Nonlinear dynamics: Chaos in space
and time. _Nature_ 404, 710–711 (2000). Article Google Scholar * Nicolis, C. & Nicolis, G. Is there a climatic attractor? _Nature_ 311, 529–532 (1984). Article ADS Google Scholar *
Bak, P., Tang, C. & Wiesenfeld, K. Self-organized criticality—an explanation of 1/F noise. _Phys. Rev. Lett._ 59, 381–384 (1987). Article ADS Google Scholar * Glass, L.
Synchronization and rhythmic processes in physiology. _Nature_ 410, 277–284 (2001). Article ADS Google Scholar * Cladis, P. E. & Palffy-Muhoray, P. _Spatio-Temporal Patterns in
Nonequilibrium Complex Systems_ (Addison-Wesley, Reading, Massachusetts, 1994). Google Scholar * Ecke, R. E., Hu, Y. C., Mainieri, R. & Ahlers, G. Excitation of spirals and
chiral-symmetry breaking in Rayleigh-Benard convection. _Science_ 269, 1704–1707 (1995). Article ADS Google Scholar * Brunet, P. & Limat, L. Defects and spatiotemporal disorder in a
pattern of falling liquid columns. _Phys. Rev. E_ 70, 046207 (2004). Article ADS Google Scholar * Ganan-Calvo, A. M. Generation of steady liquid microthreads and micron-sized monodisperse
sprays in gas streams. _Phys. Rev. Lett._ 80, 285–288 (1998). Article ADS Google Scholar * Ganan-Calvo, A. M. & Gordillo, J. M. Perfectly monodisperse microbubbling by capillary flow
focusing. _Phys. Rev. Lett._ 87, 274501 (2001). Article Google Scholar * Anna, S. L., Bontoux, N. & Stone, H. A. Formation of dispersions using ‘flow focusing’ in microchannels.
_Appl. Phys. Lett._ 82, 364–366 (2003). Article ADS Google Scholar * Garstecki, P., Stone, H. A. & Whitesides, G. M. Mechanism for flow-rate controlled breakup in confined geometries:
A route to monodisperse emulsions. _Phys. Rev. Lett._ 94, 164501 (2005). Article ADS Google Scholar * Garstecki, P. et al. Formation of monodisperse bubbles in a microfluidic
flow-focusing device. _Appl. Phys. Lett._ 85, 2649–2651 (2004). Article ADS Google Scholar * Feigenbaum, M. J. Quantitative universality for a class of non-linear transformations. _J.
Stat. Phys._ 19, 25–52 (1978). Article ADS Google Scholar * King, A. A. et al. Anatomy of a chaotic attractor: Subtle model-predicted patterns revealed in population data. _Proc. Natl
Acad. Sci. USA_ 101, 408–413 (2004). Article ADS Google Scholar * Ambravaneswaran, B., Phillips, S. D. & Basaran, O. A. Theoretical analysis of a dripping faucet. _Phys. Rev. Lett._
85, 5332–5335 (2000). Article ADS Google Scholar * Coullet, P., Mahadevan, L. & Riera, C. Hydrodynamical models for the chaotic dripping faucet. _J. Fluid Mech._ 526, 1–17 (2005).
Article ADS MathSciNet Google Scholar * Ott, E., Grebogi, C. & Yorke, J. A. Controlling chaos. _Phys. Rev. Lett._ 64, 1196–1199 (1990). Article ADS MathSciNet Google Scholar *
Ditto, W. L., Rauseo, S. N. & Spano, M. L. Experimental control of chaos. _Phys. Rev. Lett._ 65, 3211–3214 (1990). Article ADS Google Scholar * Hunt, E. R. Stabilizing high-period
orbits in a chaotic system—the diode resonator. _Phys. Rev. Lett._ 67, 1953–1955 (1991). Article ADS Google Scholar * Garfinkel, A., Spano, M. L., Ditto, W. L. & Weiss, J. N.
Controlling cardiac chaos. _Science_ 257, 1230–1235 (1992). Article ADS Google Scholar * Hudson, P. J. & Bjørnstad, O. N. Vole stranglers and lemming cycles. _Science_ 302, 797–798
(2003). Article Google Scholar * Gilg, O., Hanski, I. & Sittler, B. Cyclic dynamics in a simple vertebrate predator-prey community. _Science_ 302, 866–868 (2003). Article ADS Google
Scholar * Goldbeter, A. Computational approaches to cellular rhythms. _Nature_ 420, 238–245 (2002). Article ADS Google Scholar * Langton, C. Computation at the edge of chaos: Phase
transitions and emergent computation. _Physica D_ 42, 12–47 (1990). Article ADS MathSciNet Google Scholar Download references ACKNOWLEDGEMENTS We would like to thank L. Mahadevan
(Harvard University) for helpful discussions. P.G. acknowledges a postdoctoral fellowship from the Foundation for Polish Science. We thank the Harvard MRSEC for the use of high-speed cameras
and microfabrication facilities. This work was supported by the US Department of Energy (DE-FG02-00ER45852). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Chemistry and
Chemical Biology, Harvard University, 12 Oxford St., Cambridge, Massachusetts, USA Piotr Garstecki, Michael J. Fuerstman & George M. Whitesides * Institute of Physical Chemistry, Polish
Academy of Sciences, Kasprzaka 44/52, 01-224, Warsaw, Poland Piotr Garstecki Authors * Piotr Garstecki View author publications You can also search for this author inPubMed Google Scholar *
Michael J. Fuerstman View author publications You can also search for this author inPubMed Google Scholar * George M. Whitesides View author publications You can also search for this author
inPubMed Google Scholar CORRESPONDING AUTHORS Correspondence to Piotr Garstecki or George M. Whitesides. ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no competing financial
interests. SUPPLEMENTARY INFORMATION SUPPLEMENTARY INFORMATION (PDF 90 KB) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Garstecki, P., Fuerstman, M.
& Whitesides, G. Oscillations with uniquely long periods in a microfluidic bubble generator. _Nature Phys_ 1, 168–171 (2005). https://doi.org/10.1038/nphys176 Download citation *
Received: 07 July 2005 * Accepted: 14 October 2005 * Published: 04 December 2005 * Issue Date: 01 December 2005 * DOI: https://doi.org/10.1038/nphys176 SHARE THIS ARTICLE Anyone you share
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