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Access through your institution Buy or subscribe > low PDGF-CC expression correlated with markers of luminal breast > cancer Basal-like breast cancer, accounting for 10–15% of all
mammary carcinomas, does not express targetable oestrogen receptors (ER) and has the worst prognosis among all breast cancer subtypes. New research published in _Nature Medicine_ shows that
paracrine signalling between cancer cells and cancer-associated fibroblasts (CAFs) in basal-like breast tumours determines their molecular subtype, and therapeutic inhibition of this
crosstalk can switch subtypes from an aggressive, basal-like subtype to the more druggable luminal subtype. This is a preview of subscription content, access via your institution ACCESS
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FAQs * Contact customer support REFERENCES * Roswall, P., Bocci, B., Bartoschek, M., Li, H. Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived
growth factor-CC signaling. _Nat. Med._ https://doi.org/10.1038/nm.4494 (2018) Article CAS PubMed PubMed Central Google Scholar Download references Authors * Ulrike Harjes View author
publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Harjes, U. External
communication. _Nat Rev Cancer_ 18, 372–373 (2018). https://doi.org/10.1038/nrc.2018.30 Download citation * Published: 03 April 2018 * Issue Date: May 2018 * DOI:
https://doi.org/10.1038/nrc.2018.30 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently
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