ABSTRACT Aberrations in proteins that control apoptosis and cell survival are common in cancer. These aberrations often reside in signalling proteins that control the activation of the

apoptotic machinery or in the Bcl-2 family of proteins that control caspase activation. Recent evidence suggests that caspase 2, one of the most evolutionarily conserved caspases, may have

multiple roles in the DNA damage response, cell cycle regulation and tumour suppression. These findings are unexpected and have important implications for our understanding of tumorigenesis

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our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS CASPASE-2 REGULATES S-PHASE CELL CYCLE EVENTS TO PROTECT FROM DNA DAMAGE ACCUMULATION INDEPENDENT OF APOPTOSIS

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CAS  PubMed  PubMed Central  Google Scholar  Download references ACKNOWLEDGEMENTS I thank Donna Denton, Martin Lavin and Loretta Dorstyn for helpful comments. The work in my laboratory is

supported by the National Health and Medical Research Council of Australia and the Cancer Council of South Australia. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Haematology,

Sharad Kumar is at the Centre for Cancer Biology, SA Pathology, Frome Road, Adelaide, SA5000, Australia. [email protected], Sharad Kumar Authors * Sharad Kumar View author

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