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Access through your institution Buy or subscribe In the white adipose tissue (WAT) of obese mice fed a high-fat diet (HFD) — and specifically in resident ATMs — there were increased levels
of _Xbp1_ mRNA splicing and increased expression of ER stress markers compared with mice fed a normal chow diet, which is in line with previous studies showing that excess nutrient handling
activates the IRE1α–XBP1 pathway. Mice with a myeloid-specific knockout of IRE1α (_Ern1_f/f;_Lyz2_-Cre mice; created by the authors) were resistant to HFD-induced obesity, having lower body
weight and adiposity, decreased hyperinsulinaemia and improved insulin sensitivity; this observation couples the ER stress response of macrophages to obesity-associated metabolic
dysfunction. > lack of IRE1α enhances energy expenditure and heat production > through adaptive thermogenesis This is a preview of subscription content, access via your institution
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FAQs * Contact customer support REFERENCES * Shan, B. et al. The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity.
_Nat. Immunol._ http://dx.doi.org/10.1038/ni.3709 (2017) Download references Authors * Kirsty Minton View author publications You can also search for this author inPubMed Google Scholar
RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Minton, K. Stress-induced macrophage polarization. _Nat Rev Immunol_ 17, 277 (2017).
https://doi.org/10.1038/nri.2017.41 Download citation * Published: 10 April 2017 * Issue Date: May 2017 * DOI: https://doi.org/10.1038/nri.2017.41 SHARE THIS ARTICLE Anyone you share the
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