Access through your institution Buy or subscribe > induction of type I and type III IFNs is differentially regulated by > distinct intracellular organelles RIG-I-like receptors (RLRs)

are a family of innate immune receptors that are activated by nucleic acids and promote antiviral immunity through the induction of type I interferons (IFNs). Odendall _et al_. now report

that RLRs also induce the expression of type III IFNs in response to intracellular infection. They show that RLR-mediated induction of type I and type III IFNs is differentially regulated by

distinct intracellular organelles, and they identify peroxisomes as a major site of type III IFN expression. This is a preview of subscription content, access via your institution ACCESS

institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Odendall, C. et al. Diverse intracellular pathogens activate type III interferon expression from

peroxisomes. _Nature Immunol._ http://dx.doi.org/10.1038/ni.2915 (2014) Download references Authors * Yvonne Bordon View author publications You can also search for this author inPubMed 

Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Bordon, Y. Peroxisomes pack a distinct punch. _Nat Rev Immunol_ 14, 516–517 (2014).

https://doi.org/10.1038/nri3718 Download citation * Published: 11 July 2014 * Issue Date: August 2014 * DOI: https://doi.org/10.1038/nri3718 SHARE THIS ARTICLE Anyone you share the following

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