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Access through your institution Buy or subscribe Searching for mutant worms with morphological abnormalities in a specific motor neuron, Loria _et al_. identified UNC-75, a protein with
three RNA-recognition motifs that belongs to a group of molecules that have been implicated in splicing in other species. Importantly, the authors found that mutations in _unc-75_ did not
affect neuronal development, but specifically altered the function of cholinergic neurons in a way that resembled what has been found for mutations in synaptic-vesicle proteins. Although the
authors did not find direct evidence for the involvement of UNC-75 in splicing, they found that the protein localized to nuclear speckles, and that this localization was crucial for
restoring its function when expressed in a mutant background. Moreover, they found that a human orthologue of UNC-75, which has been shown to participate in splicing _in vitro_, could rescue
the abnormal phenotype of the mutant worm. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal
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REFERENCES ORIGINAL RESEARCH PAPER * Loria, P. M. et al. Two neuronal, nuclear-localized RNA binding proteins involved in synaptic transmission. _Curr. Biol._ 13, 1317–1323 (2003) Article
CAS Google Scholar FURTHER READING * Dredge, B. K. et al. The splice of life: alternative splicing and neurological disease. _Nature Rev. Neurosci._ 2, 43–50 (2001) Article CAS Google
Scholar Download references Authors * Juan Carlos López View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions
ABOUT THIS ARTICLE CITE THIS ARTICLE López, J. Splicing up the synapse. _Nat Rev Neurosci_ 4, 780–781 (2003). https://doi.org/10.1038/nrn1234 Download citation * Issue Date: 01 October 2003
* DOI: https://doi.org/10.1038/nrn1234 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not
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