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The application of imaging biomarkers has provided new insights into the mechanisms of damage in multiple sclerosis (MS) and the risk of MS development and progression. The goal of
eliminating all disease activity requires a timely escalation of treatment. This increasing complexity is compounded by the need to treat comorbidities. Access through your institution Buy
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which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Freeman, L. _ et
al_. The neuronal component of gray matter damage in multiple sclerosis: a [11C]flumazenil positron emission tomography study. _Ann. Neurol._ 78, 554–567 (2015). Article CAS Google Scholar
* Louapre, C. _ et al_. Beyond focal cortical lesions in MS: an _in vivo_ quantitative and spatial imaging study at 7T. _Neurology_ 85, 1702–1709 (2015). Article Google Scholar *
Salvetti, M. _ et al_. Progressive MS: from pathophysiology to drug discovery. _Mult. Scler._ 21, 1376–1384 (2015). Article CAS Google Scholar * Tintore, M. _ et al_. Defining high,
medium and low impact prognostic factors for developing multiple sclerosis. _Brain_ 138, 1863–1874 (2015). Article Google Scholar * De Stefano, N. _ et al_. Long-term assessment of no
evidence of disease activity in relapsing–remitting MS. _Neurology_ 85, 1722–1723 (2015). Article Google Scholar * Kalincik, T. _ et al_. Switch to natalizumab versus fingolimod in active
relapsing–remitting multiple sclerosis. _Ann. Neurol._ 77, 425–435 (2015). Article CAS Google Scholar * Clanet, M. C. _ et al_. Risk evaluation and monitoring in multiple sclerosis
therapeutics. _Mult. Scler._ 20, 1306–1311 (2014). Article Google Scholar * Marrie, R. A. _ et al_. Effect of comorbidity on mortality in multiple sclerosis. _Neurology_ 85, 240–247
(2015). Article Google Scholar * Marrie, R. A. _ et al_. Comorbidity delays diagnosis and increases disability at diagnosis in MS. _Neurology_ 72, 117–124 (2009). Article CAS Google
Scholar * Marrie, R. A. _ et al_. A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis: overview. _Mult. Scler._ 21, 263–281 (2015). Article Google
Scholar Download references ACKNOWLEDGEMENTS The NMR Unit and its staff are supported by the UK Multiple Sclerosis Society, National Institute for Health Research University College London
Hospitals–University College London Biomedical Research Centre, the Engineering and Physical Sciences Research Council, and University College London internal funding schemes. AUTHOR
INFORMATION AUTHORS AND AFFILIATIONS * Queen Square Multiple Sclerosis Centre, University College London Institute of Neurology and National Institute for Health Research UCL Hospitals–UCL
Biomedical Research Centre, Queen Square, BOX 9, London, WC1N 3BG, UK Olga Ciccarelli & Alan Thompson Authors * Olga Ciccarelli View author publications You can also search for this
author inPubMed Google Scholar * Alan Thompson View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Alan Thompson.
ETHICS DECLARATIONS COMPETING INTERESTS A.T. has received honoraria and support for travel for consultancy from Biogen Idec, Eisai, Genzyme, Novartis and Medday, and for speaking from
EXCEMED, Novartis, Remedica and Teva. He receives an honorarium from Sage Publications as Editor-in-Chief of _Multiple Sclerosis Journal_. O.C. serves as a consultant for Biogen, GE
Healthcare and Novartis, and payments are made to the institution; she receives an honorarium as Associate Editor of _Neurology_. POWERPOINT SLIDES POWERPOINT SLIDE FOR FIG. 1 RIGHTS AND
PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Ciccarelli, O., Thompson, A. Managing the complexity of multiple sclerosis. _Nat Rev Neurol_ 12, 70–72 (2016).
https://doi.org/10.1038/nrneurol.2016.2 Download citation * Published: 29 January 2016 * Issue Date: February 2016 * DOI: https://doi.org/10.1038/nrneurol.2016.2 SHARE THIS ARTICLE Anyone
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