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ABSTRACT Recent studies have uncovered lymphocyte factor(s) capable of enhancing erythropoiesis in vitro. The in vivo significance of this finding remains unknown. Recently a nine-year-old
boy with ALL and replaced marrow (90% lymphoblasts) presented with a [Hgb.] of 11.9g/dl. Eighty-eight % of the patient's bone marrow cells reacted with antihuman T-cell monoclonal
antibody (OKT3. pan). Sixty percent of the cells reacted with monoclonal antibody identifying helper cell function (OKT4. ind). 105 patient's T-lymphoblasts were co-cultured with 2 ×
105 normal marrow cells in methylcellulose and erythroid colonies (CFU-E) were counted. The T-lymphoblasts exerted a marked helper effect (+130%) on normal colony growth. The patient's
plasma exerted no effect. Conditioned media derived from the T-lymphoblasts similarly stimulated normal erythropoiesis (+150%). During remission the patient's [Hgb.] dropped to 7 g/dl
and his peripheral blood mononuclear cells exerted no helper effect upon normal CFU-E. During relapse concomitant with a rise in the number of blasts in the patient's bone marrow, the
[Hgb.] rose steadily and reached a level of 13.4 g/dl preterminally. Repeat studies using the patient's peripheral blood mononuclear cells (87% T-lymphoblasts) again stimulated normal
marrow CFU-E (+54%) We conclude that in this patient with T-ALL, the T-lymphoblasts exerted a stimulatory effect on erythropoiesis helping to maintain the [Hgb.] within normal limits.
ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Dept of Pediatrics, Univ. of WI., Madison, WI. J L Finlay, D J Ganick, N T Shahidi, R Hong & P Sondel * Stanford Univ.,
Stanford, CA. J L Finlay, D J Ganick, N T Shahidi, R Hong & P Sondel Authors * J L Finlay View author publications You can also search for this author inPubMed Google Scholar * D J
Ganick View author publications You can also search for this author inPubMed Google Scholar * N T Shahidi View author publications You can also search for this author inPubMed Google Scholar
* R Hong View author publications You can also search for this author inPubMed Google Scholar * P Sondel View author publications You can also search for this author inPubMed Google Scholar
RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Finlay, J., Ganick, D., Shahidi, N. _et al._ 807 T-LYMPHOBLASTS WITH ERYTHROPOIETIC HELPER FUNCTION IN
ACUTE ‘T’-CELL LEUKEMIA. _Pediatr Res_ 15 (Suppl 4), 577 (1981). https://doi.org/10.1203/00006450-198104001-00832 Download citation * Issue Date: 01 April 1981 * DOI:
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