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ABSTRACT The neurological consequences of childhood leukemia and its treatment have become increasingly important with the improvement in long-term survival. The WISC-R and Frostig Test of
Visual Perception were performed on a series of patients admitted to UCLA Medical Center for Bone Marrow Transplantation (BMT). In addition, Visual Evoked Potentials (VEP), Brainstem
Auditory Evoked Potentials (BAEP), and Somatosensory Evoked Potentials (SEP) were administered prior to BMT. Thus, the observed abnormalities reflect previous disease and/or treatment. There
were consistent findings of visual-motor deficits in 8 of 11 leukemia patients. This was evidenced in 5 patients by a profile of comparatively high scores on Picture Completion and Picture
Arrangement subtests (WISC-R) and low scores on Block Design (WISC-R) and Form Constancy (Frostig) subtests. Three of 5 patients were found to have lesions of the optic nerve on VEP while 2
of 3 patients produced slow nerve conduction studies on BAEP. Two of 4 patients had abnormal SEP. The three children with optic nerve lesions on VEP showed impairment of visual-motor skills.
These neuropsychological and electrophysiological tests are valuable in the evaluation of the long-term nervous system sequelae of childhood leukemia and its treatment. ARTICLE PDF AUTHOR
INFORMATION AUTHORS AND AFFILIATIONS * Departments of Pediatrics and Neurology, UCLA School of Medicine, Los Angeles, California Thomas A Kaleita, W Donald Shields, Melanie Dreisbach, Mark
Nuwer & Stephen A Feig Authors * Thomas A Kaleita View author publications You can also search for this author inPubMed Google Scholar * W Donald Shields View author publications You can
also search for this author inPubMed Google Scholar * Melanie Dreisbach View author publications You can also search for this author inPubMed Google Scholar * Mark Nuwer View author
publications You can also search for this author inPubMed Google Scholar * Stephen A Feig View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND
PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kaleita, T., Shields, W., Dreisbach, M. _et al._ 820 NEUROPSYCHOLOGICAL AND NEUROPHYSIOLOGICAL TESTING IN CHILDREN
WITH LEUKEMIA. _Pediatr Res_ 15 (Suppl 4), 579 (1981). https://doi.org/10.1203/00006450-198104001-00845 Download citation * Issue Date: 01 April 1981 * DOI:
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