297 effect of intrauterine growth retardation (iugr) on fatty acid sythesis

297 effect of intrauterine growth retardation (iugr) on fatty acid sythesis

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ABSTRACT The effects of IUGR on fetal triacylglycerol fatty acid (FA) synthesis was studied in 26 pregnant rats by 3H2O injection. IUGR was induced by uterine artery ligation on one horn and litters from the opposite horn served as controls. The specific activity of FA at 19 days of gestation in the liver was lower in the IUGR fetus, as compared to controls, 44.6±13 vs. 87.9±10 cpm/μmole FA, (p<.05). At 21 days of gestation, the specific activity of FA remains lower in the IUGR group, (40.6±7.8 vs. 75.8±9.8 cpm/μmole p<.05). In lung, the specific activity of FA was 25.7±5.4 cpm/μmole in IUGR fetuses as compared to 46.6±9 cpm/μmole in controls at 19 days (p<.05). This difference persisted at 21 days (32.2±2.4 vs. 42.6±3.0 cpm/μmole in IUGR and controls, respectively, p<.05). The total fatty acid content per ogran for both liver and lung was also reduced in the IUGR group. However, when expressed per unit organ weight, (gram) the IUGR fetuses have a significantly higher FA content at 21 days than the controls. This observation is probably related to a proportionally greater reduction in the accretion rates of substrates other than fat during growth. The data indicates that fetal growth retardation induced by placental vascular insufficiency is associated with reduced fat synthesis probably on the basis of reduced placental transfer of precursors for fatty acid synthesis. Similar phenomenon may be present in human IUGR infant. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Brown Univ. Program in Medicine, Women and Infants Hospital, Dept. of Ped., Providence, RI Rita A Vileisis, John N Fain & William Oh Authors * Rita A Vileisis View author publications You can also search for this author inPubMed Google Scholar * John N Fain View author publications You can also search for this author inPubMed Google Scholar * William Oh View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Vileisis, R., Fain, J. & Oh, W. 297 EFFECT OF INTRAUTERINE GROWTH RETARDATION (IUGR) ON FATTY ACID SYTHESIS. _Pediatr Res_ 15 (Suppl 4), 489 (1981). https://doi.org/10.1203/00006450-198104001-00308 Download citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-00308 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative

ABSTRACT The effects of IUGR on fetal triacylglycerol fatty acid (FA) synthesis was studied in 26 pregnant rats by 3H2O injection. IUGR was induced by uterine artery ligation on one horn and


litters from the opposite horn served as controls. The specific activity of FA at 19 days of gestation in the liver was lower in the IUGR fetus, as compared to controls, 44.6±13 vs. 87.9±10


cpm/μmole FA, (p<.05). At 21 days of gestation, the specific activity of FA remains lower in the IUGR group, (40.6±7.8 vs. 75.8±9.8 cpm/μmole p<.05). In lung, the specific activity of


FA was 25.7±5.4 cpm/μmole in IUGR fetuses as compared to 46.6±9 cpm/μmole in controls at 19 days (p<.05). This difference persisted at 21 days (32.2±2.4 vs. 42.6±3.0 cpm/μmole in IUGR


and controls, respectively, p<.05). The total fatty acid content per ogran for both liver and lung was also reduced in the IUGR group. However, when expressed per unit organ weight,


(gram) the IUGR fetuses have a significantly higher FA content at 21 days than the controls. This observation is probably related to a proportionally greater reduction in the accretion rates


of substrates other than fat during growth. The data indicates that fetal growth retardation induced by placental vascular insufficiency is associated with reduced fat synthesis probably on


the basis of reduced placental transfer of precursors for fatty acid synthesis. Similar phenomenon may be present in human IUGR infant. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND


AFFILIATIONS * Brown Univ. Program in Medicine, Women and Infants Hospital, Dept. of Ped., Providence, RI Rita A Vileisis, John N Fain & William Oh Authors * Rita A Vileisis View author


publications You can also search for this author inPubMed Google Scholar * John N Fain View author publications You can also search for this author inPubMed Google Scholar * William Oh View


author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Vileisis, R., Fain, J.


& Oh, W. 297 EFFECT OF INTRAUTERINE GROWTH RETARDATION (IUGR) ON FATTY ACID SYTHESIS. _Pediatr Res_ 15 (Suppl 4), 489 (1981). https://doi.org/10.1203/00006450-198104001-00308 Download


citation * Issue Date: 01 April 1981 * DOI: https://doi.org/10.1203/00006450-198104001-00308 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content:


Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative