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ABSTRACT ABSTRACT: Phototherapy results in the conversion of native bilirubin to more water-soluble configurational and structural isomers. The serum half-life for the configurational
isomer, the principal photoproduct _in vivo_, was determined by high pressure liquid chromatography in six premature infants following cessation of phototherapy. The mean half-life for this
isomer was 15 h. The excretion of this isomer, calculated from the measured half-life, is less than half of daily bilirubin production, and therefore cannot account for the total bilirubin
elimination observed during phototherapy. The serum concentration of the structural isomer, lumirubin, is lower than that of the configurational isomer; however, excretion is more rapid
(serum half-life < 2 h). Because of its rapid excretion, lumirubin may be an important pathway for bilirubin elimination during phototherapy. SIMILAR CONTENT BEING VIEWED BY OTHERS ACTION
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INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, Rainbow Babies and Childrens Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio John F Ennever,
Isabella Knox, Scott C Denne & William T Speck Authors * John F Ennever View author publications You can also search for this author inPubMed Google Scholar * Isabella Knox View author
publications You can also search for this author inPubMed Google Scholar * Scott C Denne View author publications You can also search for this author inPubMed Google Scholar * William T
Speck View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Ennever, J.,
Knox, I., Denne, S. _et al._ Phototherapy for Neonatal Jaundice: _in Vivo_ Clearance of Bilirubin Photoproducts. _Pediatr Res_ 19, 205–208 (1985).
https://doi.org/10.1203/00006450-198502000-00012 Download citation * Received: 22 June 1984 * Accepted: 03 October 1984 * Issue Date: 01 February 1985 * DOI:
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