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ABSTRACT In a previous work we demonstrated that in adults timing of GRH stimulation in relation to the pattern of spontaneous GH secretion could condition GH response. To investigate if
there was a similar situation in children, a GRH test (GRF-29,Serono 1 mcg/kg, iv bolus) was performed in 17 SN (8M,9F,7-11 y) and 6 GHD (3M,3F,8-12 y) at 09.30 h after an overnight fast and
30' resting. From the analysis of plasma GH variations (-30'.0') prior to stimulation, 3 theoretical phases in HSR were established: A)Secretion Phase; B)Secreticn Plateau;
C)Refractory Phase,(see fig.). GH peak after GRF-29 was evaluated according to the theoretical phase at testing. RESULTS (x±SEM).- A very high correlation (Spearman's test) was obtained
between pre-GRF GH increments (+,- or 0) and GH peak in SN (r=0.81, p<0.0001). No differences were found in the distribution per phase between M and F SN. (GH=ng/ml). While it is clear
that endogenous HSR conditions the response to GRF-29 in SN, it appears that sexual HSR dimorphism, previously reported by us, must begin after puberty, because both the sexual distribution
per phase and GH peak were very similar. The fact that SN in phase C showed similar responses to those in GHD indicates that the functional status of HSR must be taken into account to
minimize errors in diagnosis after GRH test and possibly also in GRH therapy. *p<0.005 vs.B and C. Partially supported by FISS 87/1359 ARTICLE PDF AUTHOR INFORMATION AUTHORS AND
AFFILIATIONS * Departments of Pediatrics and Physiology. Fac. of Medicine, Santiago de Compostela, Spain M Pombo, A García-Leis, R Ortigueira, L Lima & J Devesa Authors * M Pombo View
author publications You can also search for this author inPubMed Google Scholar * A García-Leis View author publications You can also search for this author inPubMed Google Scholar * R
Ortigueira View author publications You can also search for this author inPubMed Google Scholar * L Lima View author publications You can also search for this author inPubMed Google Scholar
* J Devesa View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Pombo,
M., García-Leis, A., Ortigueira, R. _et al._ HYPOTHALAMIC-SOMATOTROPH RHYTHM (HSR) AND GH RESPONSE TO GRF-29 IN SHORT NORMAL (SN) AND GI-DEFICIENT CHILDREN (GH-D). _Pediatr Res_ 23, 121
(1988). https://doi.org/10.1203/00006450-198801000-00119 Download citation * Issue Date: 01 January 1988 * DOI: https://doi.org/10.1203/00006450-198801000-00119 SHARE THIS ARTICLE Anyone you
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