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ABSTRACT In children with Congenital Heart Disease (CHD) the responsiveness of the cardiovascular system to catecholamines differs intra- and interindividually to a great extent. Since this
might be due to a dysfunction of the adrenergic system the following investigations were carried out in 18 infants with and without cyanotic CHD. Tissue from the right cardiac auricle was
taken during heart surgery. Radioligand studies, using 125-I-Cyanopindolol were carried out on these tissues to estimate the density and affinity of the β-adrenoceptors (β-R). The proportion
of β1- and β2-receptors was determined by means of displacement curves using selective β1- and β2-antagonists. 1.) The average β-R density was lower in infants with cyanotic CHD than in
those without cyanosis. The ratio of β1 - and β2-R appeared to be identical in both groups. 2.) Excessive release of noradrenalin, and even more so of adrenalin, was found. These
catecholamine levels were ten times higher than in controls. Infants with cyanotic CHD had significantly higher levels compared to those suffering from CHD without cyanosis. 3.) A linear
correlation was found between catecholamine levels and β-R density. The conclusion can be drawn that infants with CHD have an increased activation of the sympathetic nervous system. The
long-term exposition of myocardial β-R to catecholamines evidently leads to receptor desensitization. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics,
University of Düsseldorf, FRG R Kozlik, H Wicht, H H Kramer & D Reinhardt * Department of Thoracic and Cardiovascular Surgery, FRG A Krian Authors * R Kozlik View author publications You
can also search for this author inPubMed Google Scholar * H Wicht View author publications You can also search for this author inPubMed Google Scholar * H H Kramer View author publications
You can also search for this author inPubMed Google Scholar * A Krian View author publications You can also search for this author inPubMed Google Scholar * D Reinhardt View author
publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kozlik, R., Wicht, H., Kramer,
H. _et al._ THE DEVELOPMENT OF ADRENERGIC SYSTEMS IN CHILDREN WITH CONGENITAL HEART DISEASE. _Pediatr Res_ 26, 516 (1989). https://doi.org/10.1203/00006450-198911000-00100 Download citation
* Issue Date: 01 November 1989 * DOI: https://doi.org/10.1203/00006450-198911000-00100 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get
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