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ABSTRACT α1-proteinase inhibitor (α1PI) phenotypes were examined in 27 children with chronic persistent hepatitis (1st group) and in 70 newborns and infants with protracted icterus and
neonatal hepatitis (2nd group). 1442 adults and children in population study served as controls (3rd group). Prevalence of phenotype PI MZ was equal to 7.41% in the 1st group, 4,29% in the
2nd group, and 3,47% in the 3rd group. Prevalence of phenotype PI MS in the groups studied was equal to 1,87%, 2,86%, and 3,33%, respectively, α1PI phenotype PI ZZ responsible for α1PI
deficiency was not encountered in the 1st group. Its prevalence in the 2nd group reached 5,71% and in the 3rd group equaled to 0,07%. Thus, the cause of hepatitis in newborns and infants may
be attributed to α1PI deficiency approximately in 6% of cases. Hepatitis related to α1PI deficiency was characterized by persistent jaundice, hepatomegaly, elevated serum level of
conjugated and unconjugated bilirubin and hemorrhagic syndrome. ARTICLE PDF AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pediatrics, Vilnius State University, Vilnius,
Lithuanian SSR, USSR Petras Kaltenis & Vytautas Basys Authors * Petras Kaltenis View author publications You can also search for this author inPubMed Google Scholar * Vytautas Basys View
author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Kaltenis, P., Basys, V.
SIGNIFICANCE OF α1-PROTEINASE INHIBITOR DEFICIENCY IN ETIOPATHOGENESIS OF LIVER DISEASES IN CHILDREN. _Pediatr Res_ 26, 516 (1989). https://doi.org/10.1203/00006450-198911000-00103 Download
citation * Issue Date: 01 November 1989 * DOI: https://doi.org/10.1203/00006450-198911000-00103 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content:
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