Effect of gestational age on pulsatile secretion of plasma cortisol in neonates using deconvolution analysis. † 809

Effect of gestational age on pulsatile secretion of plasma cortisol in neonates using deconvolution analysis. † 809

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Cortisol (F) is secreted in discrete pulses at approx 65 min intervals in neonates. The aim of this study was to assess the effect of gestational age on such pulsatile F secretion. Blood samples for plasma F were taken via indwelling arterial lines at 15 min intervals for 6 hours in neonates not exposed to antenatal steroids < 7 days before being studied. Clinically stable neonates were studied in the first 9 postnatal days. Characteristics of F secretion were estimated by deconvolution analysis. Neonates were studied in three gestational age groups: < 34 wks (median ga 31 wks, bw 1.57 kg, n=18), 34-36 wks (median ga 35 wks, bw 2.72 kg, n=7) and > 36 wks (median ga 38 wks, bw 3.51 kg, n=9). Pulsatile F secretion was observed in all infants. Data in the Table are given as median and inter-quartile range. Extrapolating to 24h, and correcting for volume of distribution of F and body surface area, we estimated median endogenous F production rate for the ga groups < 34 wks, 34-36 wks, and > 36 wks as 5.8, 4.5, and 7.6 mg/m2.24h, respectively. We conclude that F production rate is not influenced by gestational age in clinically stable neonates. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Dept Neonatology, Royal North Shore Hospital, Sydney, Australia, Dept Internal Medicine, Univ Virginia Health Sciences Center, Charlottesville, Virginia, Dept Endocrinology, New Children's Hospital, Sydney, Australia John D Arnold, Gill Bonacruz, Garth I Leslie, Johannes D Veldhuis, Darna Milmlow & Martin Silink Authors * John D Arnold View author publications You can also search for this author inPubMed Google Scholar * Gill Bonacruz View author publications You can also search for this author inPubMed Google Scholar * Garth I Leslie View author publications You can also search for this author inPubMed Google Scholar * Johannes D Veldhuis View author publications You can also search for this author inPubMed Google Scholar * Darna Milmlow View author publications You can also search for this author inPubMed Google Scholar * Martin Silink View author publications You can also search for this author inPubMed Google Scholar ADDITIONAL INFORMATION (Spon by: John C. Sinclair) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Arnold, J., Bonacruz, G., Leslie, G. _et al._ Effect of Gestational Age on Pulsatile Secretion of Plasma Cortisol in Neonates Using Deconvolution Analysis. † 809. _Pediatr Res_ 41 (Suppl 4), 137 (1997). https://doi.org/10.1203/00006450-199704001-00829 Download citation * Issue Date: 01 April 1997 * DOI: https://doi.org/10.1203/00006450-199704001-00829 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative

Cortisol (F) is secreted in discrete pulses at approx 65 min intervals in neonates. The aim of this study was to assess the effect of gestational age on such pulsatile F secretion. Blood


samples for plasma F were taken via indwelling arterial lines at 15 min intervals for 6 hours in neonates not exposed to antenatal steroids < 7 days before being studied. Clinically


stable neonates were studied in the first 9 postnatal days. Characteristics of F secretion were estimated by deconvolution analysis. Neonates were studied in three gestational age groups:


< 34 wks (median ga 31 wks, bw 1.57 kg, n=18), 34-36 wks (median ga 35 wks, bw 2.72 kg, n=7) and > 36 wks (median ga 38 wks, bw 3.51 kg, n=9). Pulsatile F secretion was observed in all


infants. Data in the Table are given as median and inter-quartile range. Extrapolating to 24h, and correcting for volume of distribution of F and body surface area, we estimated median


endogenous F production rate for the ga groups < 34 wks, 34-36 wks, and > 36 wks as 5.8, 4.5, and 7.6 mg/m2.24h, respectively. We conclude that F production rate is not influenced by


gestational age in clinically stable neonates. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Dept Neonatology, Royal North Shore Hospital, Sydney, Australia, Dept Internal Medicine, Univ


Virginia Health Sciences Center, Charlottesville, Virginia, Dept Endocrinology, New Children's Hospital, Sydney, Australia John D Arnold, Gill Bonacruz, Garth I Leslie, Johannes D


Veldhuis, Darna Milmlow & Martin Silink Authors * John D Arnold View author publications You can also search for this author inPubMed Google Scholar * Gill Bonacruz View author


publications You can also search for this author inPubMed Google Scholar * Garth I Leslie View author publications You can also search for this author inPubMed Google Scholar * Johannes D


Veldhuis View author publications You can also search for this author inPubMed Google Scholar * Darna Milmlow View author publications You can also search for this author inPubMed Google


Scholar * Martin Silink View author publications You can also search for this author inPubMed Google Scholar ADDITIONAL INFORMATION (Spon by: John C. Sinclair) RIGHTS AND PERMISSIONS


Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Arnold, J., Bonacruz, G., Leslie, G. _et al._ Effect of Gestational Age on Pulsatile Secretion of Plasma Cortisol in Neonates


Using Deconvolution Analysis. † 809. _Pediatr Res_ 41 (Suppl 4), 137 (1997). https://doi.org/10.1203/00006450-199704001-00829 Download citation * Issue Date: 01 April 1997 * DOI:


https://doi.org/10.1203/00006450-199704001-00829 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is


not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative