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Cortisol (F) is secreted in discrete pulses at approx 65 min intervals in neonates. The aim of this study was to assess the effect of gestational age on such pulsatile F secretion. Blood
samples for plasma F were taken via indwelling arterial lines at 15 min intervals for 6 hours in neonates not exposed to antenatal steroids < 7 days before being studied. Clinically
stable neonates were studied in the first 9 postnatal days. Characteristics of F secretion were estimated by deconvolution analysis. Neonates were studied in three gestational age groups:
< 34 wks (median ga 31 wks, bw 1.57 kg, n=18), 34-36 wks (median ga 35 wks, bw 2.72 kg, n=7) and > 36 wks (median ga 38 wks, bw 3.51 kg, n=9). Pulsatile F secretion was observed in all
infants. Data in the Table are given as median and inter-quartile range. Extrapolating to 24h, and correcting for volume of distribution of F and body surface area, we estimated median
endogenous F production rate for the ga groups < 34 wks, 34-36 wks, and > 36 wks as 5.8, 4.5, and 7.6 mg/m2.24h, respectively. We conclude that F production rate is not influenced by
gestational age in clinically stable neonates. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Dept Neonatology, Royal North Shore Hospital, Sydney, Australia, Dept Internal Medicine, Univ
Virginia Health Sciences Center, Charlottesville, Virginia, Dept Endocrinology, New Children's Hospital, Sydney, Australia John D Arnold, Gill Bonacruz, Garth I Leslie, Johannes D
Veldhuis, Darna Milmlow & Martin Silink Authors * John D Arnold View author publications You can also search for this author inPubMed Google Scholar * Gill Bonacruz View author
publications You can also search for this author inPubMed Google Scholar * Garth I Leslie View author publications You can also search for this author inPubMed Google Scholar * Johannes D
Veldhuis View author publications You can also search for this author inPubMed Google Scholar * Darna Milmlow View author publications You can also search for this author inPubMed Google
Scholar * Martin Silink View author publications You can also search for this author inPubMed Google Scholar ADDITIONAL INFORMATION (Spon by: John C. Sinclair) RIGHTS AND PERMISSIONS
Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Arnold, J., Bonacruz, G., Leslie, G. _et al._ Effect of Gestational Age on Pulsatile Secretion of Plasma Cortisol in Neonates
Using Deconvolution Analysis. † 809. _Pediatr Res_ 41 (Suppl 4), 137 (1997). https://doi.org/10.1203/00006450-199704001-00829 Download citation * Issue Date: 01 April 1997 * DOI:
https://doi.org/10.1203/00006450-199704001-00829 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is
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