ABSTRACT OBJECTIVES Obesity is characterized by excessive fat accumulation due to an imbalance between energy intake and expenditure. Osmotin, a plant derived natural protein, is a known

homolog of adiponectin. To analyze the role of Osmotin in controlling energy metabolism by suppressing abdominal fat accumulation. METHODS We investigated the effects of osmotin in C57BL/6

mice on high-fat diet and in 3T3-L1 adipocytes by Biochemical tests, Immunofluorescence confocal Microscopy, RT-PCR, and Flow cytometry. RESULTS In this study, we investigated the

anti-obesity effects of osmotin on adipocyte differentiation and regulation of the related factors lipolysis and glucose uptake in 3T3-L1 cells in vitro. Moreover, we analyzed the role of

the role of osmotin in AMPK downstream signaling. These results provide the first indication that osmotin exerts therapeutic effects on obesity, which could promote development of

therapeutic aspects for obesity and related diseases. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS

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institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS PYRAZOLONE DERIVATIVE C29 PROTECTS AGAINST HFD-INDUCED OBESITY IN MICE VIA

ACTIVATION OF AMPK IN ADIPOSE TISSUE Article 15 September 2020 IL-27 ALLEVIATES HIGH-FAT DIET-INDUCED OBESITY AND METABOLIC DISORDERS BY INHIBITING ADIPOGENESIS VIA ACTIVATING HDAC6 Article

Open access 19 March 2025 ANTI-OBESITY EFFECTS OF THE DUAL-ACTIVE ADENOSINE A2A/A3 RECEPTOR-LIGAND LJ-4378 Article Open access 27 September 2022 REFERENCES * Ng M, Fleming T, Robinson M,

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research was supported by the Brain Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT (NRF-2016M3C7A1904391). AUTHOR INFORMATION

Author notes * These authors contributed equally: Min Gi Jo, Min Woo Kim, Myeung Hoon Jo AUTHORS AND AFFILIATIONS * Division of Life Science and Applied Life Science (BK21 plus), College of

Natural Sciences, Gyeongsang National University, Jinju, 52802, Republic of Korea Min Gi Jo, Min Woo Kim, Myeung Hoon Jo, Noman bin Abid & Myeong Ok Kim Authors * Min Gi Jo View author

publications You can also search for this author inPubMed Google Scholar * Min Woo Kim View author publications You can also search for this author inPubMed Google Scholar * Myeung Hoon Jo

View author publications You can also search for this author inPubMed Google Scholar * Noman bin Abid View author publications You can also search for this author inPubMed Google Scholar *

Myeong Ok Kim View author publications You can also search for this author inPubMed Google Scholar CONTRIBUTIONS MGJ conceived the hypothesis, designed the research, performed overall

experiments, wrote manuscript, and performed data analysis. MWK and MHJ designed the research and performed the in vivo experiments, calculations, and data analysis. NBA contributed to the

discussion and edited the manuscript. All authors approved the results and the final version of this manuscript. MOK revised the manuscript and holds all responsibilities related to this

manuscript as the corresponding author. CORRESPONDING AUTHOR Correspondence to Myeong Ok Kim. ETHICS DECLARATIONS CONFLICT OF INTEREST The authors declare that they have no conflict of

interest. ETHICAL APPROVAL The experimental procedures of animal care and treatment minimized the number of mice and their suffering and were approved by the Animal Ethics Committee (IACUC)

of the Division of Applied Life Sciences, Department of Biology at Gyeongsang National University, Republic of Korea (Approval ID: 125). ADDITIONAL INFORMATION PUBLISHER’S NOTE: Springer

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RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Jo, M.G., Kim, M.W., Jo, M.H. _et al._ Adiponectin homolog osmotin, a potential anti-obesity compound,

suppresses abdominal fat accumulation in C57BL/6 mice on high-fat diet and in 3T3-L1 adipocytes. _Int J Obes_ 43, 2422–2433 (2019). https://doi.org/10.1038/s41366-019-0383-3 Download

citation * Received: 13 September 2018 * Revised: 26 March 2019 * Accepted: 01 April 2019 * Published: 04 June 2019 * Issue Date: December 2019 * DOI:

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