ABSTRACT Metabolic reprogramming fulfils increased nutrient demands and regulates numerous oncogenic processes in tumors, leading to tumor malignancy. Branched-chain amino acids (BCAAs,

i.e., valine, leucine, and isoleucine) function as nitrogen donors to generate macromolecules such as nucleotides and are indispensable for human cancer cell growth. The cell-autonomous and

non-autonomous roles of altered BCAA metabolism have been implicated in cancer progression and the key proteins in the BCAA metabolic pathway serve as possible prognostic and diagnostic

biomarkers in human cancers. Here we summarize how BCAA metabolic reprogramming is regulated in cancer cells and how it influences cancer progression. Access through your institution Buy or

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AMINO ACID METABOLISM IN TUMOR BIOLOGY AND THERAPY Article Open access 13 January 2024 EMERGING MECHANISMS AND PROMISING APPROACHES IN PANCREATIC CANCER METABOLISM Article Open access 01

August 2024 EXPLORING METABOLIC REPROGRAMMING IN ESOPHAGEAL CANCER: THE ROLE OF KEY ENZYMES IN GLUCOSE, AMINO ACID, AND NUCLEOTIDE PATHWAYS AND TARGETED THERAPIES Article 10 January 2025

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survival in patients with liver cirrhosis. Digestive Dis (Basel, Switz). 2011;29:326–32. Google Scholar  Download references ACKNOWLEDGEMENTS Work in authors’ laboratories was supported by

grants from NIH (R01CA222393), CPRIT (RP190358), Mary Kay Foundation (08–19), and Welch Foundation (I-1903-20190330) to WL; and NIH (R01AG066166, R35GM124693) and UTSW startup funds to YW.

WL is a CPRIT Scholar in Cancer Research. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd.,

Dallas, TX, 75390, USA Hui Peng, Yingfei Wang & Weibo Luo * Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA

Yingfei Wang * Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA Weibo Luo Authors * Hui Peng View author

publications You can also search for this author inPubMed Google Scholar * Yingfei Wang View author publications You can also search for this author inPubMed Google Scholar * Weibo Luo View

author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHORS Correspondence to Yingfei Wang or Weibo Luo. ETHICS DECLARATIONS CONFLICT OF INTEREST

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