Play all audios:
ABSTRACT The main milestones in the exploration and validation of cancer breathprint for the advancement of personalised diagnosis and medicine are summarised here, with a special attention
to the appraisal and translation of the accumulating knowledge from the laboratory to the Point-of-Care phase. An outlook into the opportunities of the use of breathprints and their wider
availability for healthcare is offered. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through
your institution Subscribe to this journal Receive 24 print issues and online access $259.00 per year only $10.79 per issue Learn more Buy this article * Purchase on SpringerLink * Instant
access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions *
Read our FAQs * Contact customer support REFERENCES * Phillips M. Breath tests in medicine. Sci Am. 192;267:74–9. * Hakim M, Broza YY, Barash O, Peled N, Phillips M, Amann A, et al. Volatile
organic compounds of lung cancer and possible biochemical pathways. Chem Rev. 2012;112:5949–66. Article CAS PubMed Google Scholar * Broza YY, Vishinkin R, Barash O, Nakhleh MK, Haick H.
Synergy between nanomaterials and volatile organic compounds for non-invasive medical evaluation. Chem Soc Rev. 2018;47:4781–859. Article CAS PubMed Google Scholar * Peng G, Hakim M,
Broza YY, Billan S, Abdah-Bortnyak R, Kuten A, et al. Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors. Br J Cancer.
2010;103:542–51. * Hakim M, Billan S, Tisch U, Peng G, Dvorkind I, Marom O, et al. Diagnosis of head-and-neck cancer from exhaled breath. Br J Cancer. 2011;104:1649–55. Article CAS PubMed
PubMed Central Google Scholar * Nakhleh MK, Amal H, Jeries R, Broza YY, Aboud M, Gharra A, et al. Diagnosis and classification of 17 diseases from 1404 subjects via pattern analysis of
exhaled molecules. ACS Nano. 2017;11:112–25. Article CAS PubMed Google Scholar * Amal H, Leja M, Funka K, Skapars R, Sivins A, Ancans G, et al. Detection of precancerous gastric lesions
and gastric cancer through exhaled breath. Gut. 2016;65:400–7. Article CAS PubMed Google Scholar * Xu ZQ, Ionsecu R, Broza Y, Tisch U, Ding L, Liu H, et al. A nanomaterial-based breath
test for distinguishing gastric cancer from benign gastric conditions. Br J Cancer. 2013;108:941–50. Article CAS PubMed PubMed Central Google Scholar * Shlomi D, Abud M, Liran O, Bar J,
Gai-Mor N, Ilouze M, et al. Detection of lung cancer and EGFR mutation by electronic nose system. J Thorac Oncol. 2017;12:1544–51. Article PubMed Google Scholar * Barash O, Zhang W,
Halpern JM, Hua QL, Pan YP, Kayal H, et al. Differentiation between genetic mutations of breast cancer by breath volatolomics. Oncotarget. 2015;6:44864–76. Article PubMed PubMed Central
Google Scholar Download references ACKNOWLEDGEMENTS The author thanks all researchers and students in the LNBD group as well as collaborators through the years for their thorough, excellent
and fruitful contributions and partnership. FUNDING None. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Chemical Engineering and Department of Biomedical Engineering,
Technion—Israel Institute of Technology, Haifa, 3200003, Israel Hossam Haick Authors * Hossam Haick View author publications You can also search for this author inPubMed Google Scholar
CONTRIBUTIONS H.H. wrote and proofed this comment. CORRESPONDING AUTHOR Correspondence to Hossam Haick. ETHICS DECLARATIONS COMPETING INTERESTS The author declares no competing interests.
ETHICS APPROVAL AND CONSENT TO PARTICIPATE Not applicable. CONSENT TO PUBLISH Not applicable. ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with regard to
jurisdictional claims in published maps and institutional affiliations. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Haick, H. The diagnostic
breathprint of cancer; the past and the future. _Br J Cancer_ 128, 448–450 (2023). https://doi.org/10.1038/s41416-022-01987-0 Download citation * Received: 27 July 2022 * Revised: 26 August
2022 * Accepted: 07 September 2022 * Published: 19 October 2022 * Issue Date: 02 February 2023 * DOI: https://doi.org/10.1038/s41416-022-01987-0 SHARE THIS ARTICLE Anyone you share the
following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer
Nature SharedIt content-sharing initiative