ABSTRACT BACKGROUND/OBJECTIVES Sarcopenia defined by the association of skeletal muscle mass depletion and a decreased physical performance is underdiagnosed in chronic obstructive pulmonary

disease (COPD) patients. The objective was to assess prevalence of sarcopenia and malnutrition in hospitalized COPD patients during an acute exacerbation, after 6 months follow-up and the

1-year survival. SUBJECTS/METHODS Hospitalized COPD patients were recruited for the assessment of body composition, handgrip strength, respiratory function, and maximal inspiratory and

expiratory pressures (MIP and MEP), during hospitalization and 6 months later. Sarcopenia was defined according to the criteria of the European Working Group on Sarcopenia in Older Adults,

30% after 6 months. MIP and MEP were lower in sarcopenic patients (_p_ = 0.01 and 0.009, respectively). In multivariate analysis, skeletal muscle mass index and MIP were positively

correlated at 6 months’ follow-up (_r_ = 0.40, _p_ = 0.04). The 1-year survival rate was lower in sarcopenic patients (65 vs 86%, _p_ = 0.03), particularly when malnutrition was associated

(_p_ = 0.02). CONCLUSIONS Sarcopenia in COPD patients is highly prevalent during and after recovery of an acute exacerbation, exposing to lower survival. A multimodal management is required

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PULMONARY DISEASE Article Open access 18 March 2024 RESPIRATORY MUSCLE STRENGTH CAN IMPROVE THE PROGNOSTIC ASSESSMENT IN COPD Article Open access 29 May 2024 PREDICTION OF SARCOPENIA USING A

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Download references ACKNOWLEDGEMENTS The authors wish to acknowledge the Respiratory and Clinical Nutrition Departments of the University Hospital of Clermont-Ferrand for their assistance in

collecting data in this study. AUTHOR INFORMATION Author notes * L. Perrot Present address: Perrot Loïc, 42 Boulevard Jourdan, 75016, Paris, France AUTHORS AND AFFILIATIONS * CHU

Clermont-Ferrand, Service de Pneumologie, Clermont-Ferrand, France L. Perrot, A. Greil & D. Caillaud * CHU Clermont-Ferrand, Service de Nutrition Clinique, Clermont-Ferrand, France Y.

Boirie & N. Farigon * Université Clermont Auvergne, INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, Clermont-Ferrand, France Y. Boirie & F. Costes * CHU Clermont-Ferrand,

Délégation à la Recherche Clinique et l’Innovation, Clermont-Ferrand, France A. Mulliez * CHU Clermont-Ferrand, Service de Médecine du Sport et explorations fonctionnelles respiratoires,

Clermont-Ferrand, France F. Costes Authors * L. Perrot View author publications You can also search for this author inPubMed Google Scholar * A. Greil View author publications You can also

search for this author inPubMed Google Scholar * Y. Boirie View author publications You can also search for this author inPubMed Google Scholar * N. Farigon View author publications You can

also search for this author inPubMed Google Scholar * A. Mulliez View author publications You can also search for this author inPubMed Google Scholar * F. Costes View author publications You

can also search for this author inPubMed Google Scholar * D. Caillaud View author publications You can also search for this author inPubMed Google Scholar CONTRIBUTIONS LP, AG, YB, NF, and

FC conceived the study; LP carried out the study, managed, and analyzed data; LP and AM performed the statistical analysis; LP drafted the manuscript; AG, YB, FC, and DC reviewed the

manuscript. All authors read and approved the final manuscript. CORRESPONDING AUTHOR Correspondence to L. Perrot. ETHICS DECLARATIONS CONFLICT OF INTEREST The authors declare that they have

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AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Perrot, L., Greil, A., Boirie, Y. _et al._ Prevalence of sarcopenia and malnutrition during acute exacerbation

of COPD and after 6 months recovery. _Eur J Clin Nutr_ 74, 1556–1564 (2020). https://doi.org/10.1038/s41430-020-0623-6 Download citation * Received: 06 December 2019 * Revised: 15 March 2020

* Accepted: 23 March 2020 * Published: 15 April 2020 * Issue Date: November 2020 * DOI: https://doi.org/10.1038/s41430-020-0623-6 SHARE THIS ARTICLE Anyone you share the following link with

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