ABSTRACT BACKGROUND/ OBJECTIVES Nutrition support is frequently required post allogeneic haematopoietic progenitor cell transplantation (HPCT) however the tolerance of enteral nutrition (EN)

can vary. This mixed methods study aimed to explore staff perceptions, barriers and enablers to the use of EN post HPCT and report the implementation and outcomes of a nutrition protocol.

SUBJECT/ METHODS A survey on barriers and enablers to the use of EN was developed and distributed to medical and nursing staff. Data on nutrition and clinical outcomes was collected for 12

months post implementation of a new nutrition protocol. RESULTS Thirty staff completed the survey, key barriers identified included uncertain EN tolerance, lack of confidence in nasogastric

higher proportion of malnourished patients receiving PN (23% vs 5%). Patients who received PN had a longer length of hospital stay (median 22 vs 19 days, _p_ = 0.012) and lower rate of

survival to day 100 (81% vs 95%, _p_ = 0.036) than patients who received EN. CONCLUSION The use of EN may lead to improved clinical outcomes compared to PN therefore should be implemented as

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our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS NUTRITION SUPPORT AND CLINICAL OUTCOMES FOLLOWING ALLOGENEIC STEM CELL TRANSPLANTATION Article 04 August 2023 THE

EUROPEAN SOCIETY FOR BLOOD AND MARROW TRANSPLANTATION (EBMT) ROADMAP AND PERSPECTIVES TO IMPROVE NUTRITIONAL CARE IN PATIENTS UNDERGOING HEMATOPOIETIC STEM CELL TRANSPLANTATION ON BEHALF OF

THE CELLULAR THERAPY AND IMMUNOBIOLOGY WORKING PARTY (CTIWP) AND THE NURSES GROUP (NG) OF THE EBMT Article 05 July 2023 OPTIMIZATION OF NUTRITION SUPPORT PRACTICES EARLY AFTER HEMATOPOIETIC

CELL TRANSPLANTATION Article 10 October 2020 DATA AVAILABILITY The datasets analysed during the current study are not publicly available due to ethics requirements. REFERENCES * Dietrich S,

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  PubMed  PubMed Central  Google Scholar  Download references FUNDING This research was supported by grants from the Royal Brisbane & Women’s Hospital Research Foundation. The funding

body has no role in the study design, data collection, analysis, interpretation or in the manuscript preparation. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * School of Human Movement and

Nutrition Sciences, University of Queensland, St Lucia, QLD, 4072, Australia Sarah Andersen, Merrilyn Banks & Teresa Brown * Department of Dietetics and Foodservices, Royal Brisbane and

Women’s Hospital, Butterfield Street, Herston, QLD, 4029, Australia Sarah Andersen, Rebecca Fichera, Merrilyn Banks & Teresa Brown * Department of Clinical Haematology, Royal Brisbane

and Women’s Hospital, Butterfield Street, Herston, QLD, 4029, Australia Glen Kennedy, Nicholas Weber & David Williams * Department of Nutrition, Dietetics and Food, Monash University,

Melbourne, VIC, 3168, Australia Judy Bauer Authors * Sarah Andersen View author publications You can also search for this author inPubMed Google Scholar * Rebecca Fichera View author

publications You can also search for this author inPubMed Google Scholar * Merrilyn Banks View author publications You can also search for this author inPubMed Google Scholar * Teresa Brown

View author publications You can also search for this author inPubMed Google Scholar * Glen Kennedy View author publications You can also search for this author inPubMed Google Scholar *

Nicholas Weber View author publications You can also search for this author inPubMed Google Scholar * David Williams View author publications You can also search for this author inPubMed 

Google Scholar * Judy Bauer View author publications You can also search for this author inPubMed Google Scholar CONTRIBUTIONS Phase one study: SA: conceptualisation, methodology, funding

acquisition, investigation, formal analysis, writing original draught, writing review and editing, project administration. NW: methodology, writing review and editing. TB: methodology,

writing review and editing. GK: methodology, writing review and editing. MB: conceptualisation, methodology, writing review and editing. JB: conceptualisation, methodology, writing review

and editing. Phase two study: SA: conceptualisation, methodology, investigation, formal analysis, writing original draught, writing review and editing. RF: conceptualisation, methodology,

investigation, writing review and editing. TB: methodology, writing review and editing. GK: methodology, writing review and editing. MB: methodology, writing review and editing. JB: writing

review and editing. DW: methodology, writing review and editing. All authors have read and approved the final manuscript. CORRESPONDING AUTHOR Correspondence to Sarah Andersen. ETHICS

DECLARATIONS COMPETING INTERESTS The authors declare no competing interests. ETHICAL APPROVAL Phase one study: Approved by the RBWH Human Research Ethics Committee (HREC/18/QRBW/321) and

University of Queensland Human Research Ethics Board (approval 2018001520). Phase two study: received an exemption from ethics approval from the RBWH Human Research Ethics Committee.

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SUPPLEMENTARY INFORMATION 1 RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Andersen, S., Fichera, R., Banks, M. _et al._ Proactive enteral nutrition for

patients undergoing allogeneic stem cell transplantation- implementation and clinical outcomes. _Eur J Clin Nutr_ 78, 251–256 (2024). https://doi.org/10.1038/s41430-023-01367-8 Download

citation * Received: 22 March 2022 * Revised: 21 October 2023 * Accepted: 30 October 2023 * Published: 15 November 2023 * Issue Date: March 2024 * DOI:

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