ABSTRACT Inflatable penile prosthesis (IPP) surgery is an effective, safe and satisfactory treatment option for medication-refractory erectile dysfunction. Postoperative complications

include infection, mechanical failure, erosion, and pain. Current literature suggests the need for a better approach to postoperative pain management after IPP surgery. Clinical studies have

demonstrated that postoperative pain is different in diabetic patients. We sought to determine if there is a difference in pain after IPP placement in diabetics. This is a

single-institution retrospective review. The main outcome measure was the number of 30-day postoperative visits for pain. The secondary outcome included differences in how pain was managed.

were more likely to be managed with opioids and gabapentin (30% vs 14%, _p_ = 0.05). There were no statistical differences in age between diabetics and non-diabetics (mean 59 vs 61, _p_ = 

0.193). Hispanic and African-American patients represented 87% of the poorly controlled diabetics compared with only 13% of white patients (_p_ < 0.001). Poorly controlled diabetics had

more medical comorbidities (_p_ < 0.001). On logistic regression, a HbA1c > 8 was predictive of an unplanned visit for pain with an OR of 2.83 (_p_ = 0.04). Significant pain after IPP

surgery was higher in diabetics with HbA1c > 8, which resulted in more unplanned 30-day postoperative visits. Patients with significant postoperative pain were managed with a combination

of opioids and gabapentin. Future studies are required to optimize pain management in diabetics following IPP placement. Access through your institution Buy or subscribe This is a preview of

subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $259.00 per year only

$21.58 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout

ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS EARLY COMPLICATIONS AFTER

PENILE PROSTHESIS SURGERY: FINDINGS FROM THE PHOENIX MULTICENTER REGISTRY Article 07 May 2025 PENOSCROTAL INFLATABLE PENILE PROSTHESIS RECIPIENTS OFTEN FULLY RECOVER FROM PAIN AT TWO WEEKS

FOLLOWING PLACEMENT Article 01 April 2024 RISK FACTORS FOR REOPERATION OF INFLATABLE PENILE PROSTHESIS AMONG AN ETHNICALLY DIVERSE URBAN POPULATION IN A HIGH-VOLUME CENTER Article Open

access 26 August 2024 REFERENCES * Montague DK, Jarow JP, Broderick GA, Dmochowski RR, Heaton JP, Lue TF, Erectile Dysfunction Guideline Update Panel et al. Chapter 1: The management of

erectile dysfunction: an AUA update. J Urol. 2005;174:230–9. Article  Google Scholar  * Hatzimouratidis K, Amar E, Eardley I, Giuliano F, Hatzichristou D, Montorsi F, European Association of

Urology et al. Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation. Eur Urol. 2010;57:804–14. Article  Google Scholar  * Vakalopoulos I, Kampantais S,

Ioannidis S, Laskaridis L, Dimopoulos P, Toutziaris C, et al. High patient satisfaction after inflatable penile prostheses implantation correlates with female partner satisfaction. J Sex

Med. 2013;10:2774–81. Article  Google Scholar  * Scherzer ND, Dick B, Gabrielson AT, Alzweri LM, Hellstrom WJG. Penile prosthesis complications: planning, prevention, and decision making.

Sex Med Rev. 2019;7:349–59. Article  Google Scholar  * Gross M. Penile prosthesis infection. AUA Update Ser. 2018;37:109–16. Google Scholar  * Berglund DD, Kurowicki J, Giveans MR, Horn B,

Levy JC. Comorbidity effect on speed of recovery after arthroscopic rotator cuff repair. JSES Open Access. 2018;2:60–8. Article  Google Scholar  * Barbera L, Sutradhar R, Howell D, Corn E,

O’Brien MA, Seow H, et al. Factors associated with opioid use in long term cancer survivors. J Pain Symptom Manag. 2019;58:100–107. Article  Google Scholar  * Kirk JK, Hunter JC, Mihalko SL,

Danhauer SC, Shumaker SA. Perspectives of pain in patients with type 2 diabetes. Expert Rev Endocrinol Metab. 2019;14:215–9. Article  CAS  Google Scholar  * Gwathmey KG, Pearson KT.

Diagnosis and management of sensory polyneuropathy. BMJ. 2019;365:l1108. Article  Google Scholar  * Robinson-Papp J, George MC, Dorfman D, Simpson DM. Barriers to chronic pain measurement: a

qualitative study of patient perspectives. Pain Med. 2015;16:1256–64. Article  Google Scholar  * Bril V, England J, Franklin GM, Backonja M, Cohen J, Del Toro D, et al. Evidence-based

guideline: Treatment of painful diabetic neuropathy: report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American

Academy of Physical Medicine and Rehabilitation. PM R. 2011;3:345–52. Article  Google Scholar  * Adams AS, Parker MM, Moffet HH, Jaffe M, Schillinger D, Callaghan B, et al. Communication

barriers and the clinical recognition of diabetic peripheral neuropathy in a diverse cohort of adults: the DISTANCE study. J Health Commun. 2016;21:544–53. Article  Google Scholar  * He P,

Hu Y, Li C, Wu D, Ge S, Liu T. Predictors of depressive symptoms among mid-aged and older men with diabetes in China. Res Theory Nurs Pr. 2019;33:6–22. Article  Google Scholar  * Shah A,

Hayes CJ, Martin BC. Characteristics of initial prescription episodes and likelihood of long-term opioid use—United States, 2006–2015. MMWR Morb Mortal Wkly Rep. 2017;66:265–9. Article 

Google Scholar  * Scherrer JF, Salas J, Schneider FD, Bucholz KK, Sullivan MD, Copeland LA, et al. Characteristics of new depression diagnoses in patients with and without prior chronic

opioid use. J Affect Disord. 2017;210:125–9. Article  Google Scholar  * Bădescu SV, Tătaru C, Kobylinska L, Georgescu EL, Zahiu DM, Zăgrean AM, et al. The association between diabetes

mellitus and depression. J Med Life. 2016;9:120–5. PubMed  PubMed Central  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Dartmouth-Hitchcock Medical

Center, New Hampshire, NH, USA Lael Reinstatler, Briana Goddard, Michael Rezaee & Martin Gross * Boston University School of Medicine, Boston, MA, USA Dayron Rodríguez, Michel Apoj &

 Ricardo Munarriz Authors * Lael Reinstatler View author publications You can also search for this author inPubMed Google Scholar * Dayron Rodríguez View author publications You can also

search for this author inPubMed Google Scholar * Briana Goddard View author publications You can also search for this author inPubMed Google Scholar * Michel Apoj View author publications

You can also search for this author inPubMed Google Scholar * Michael Rezaee View author publications You can also search for this author inPubMed Google Scholar * Martin Gross View author

publications You can also search for this author inPubMed Google Scholar * Ricardo Munarriz View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING

AUTHOR Correspondence to Ricardo Munarriz. ETHICS DECLARATIONS CONFLICT OF INTEREST Ricardo Munarriz and Martin Gross are consultants for Coloplast. ADDITIONAL INFORMATION PUBLISHER’S NOTE

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE

THIS ARTICLE Reinstatler, L., Rodríguez, D., Goddard, B. _et al._ Postoperative penile prosthesis pain: is it worse in diabetic patients?. _Int J Impot Res_ 33, 286–290 (2021).

https://doi.org/10.1038/s41443-020-0284-y Download citation * Received: 17 October 2019 * Revised: 08 January 2020 * Accepted: 08 April 2020 * Published: 23 April 2020 * Issue Date: April

2021 * DOI: https://doi.org/10.1038/s41443-020-0284-y SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable

link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative