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Combining genomics data from the TRACERx non-small-cell lung cancer (NSCLC) cohort and experimental data, we report that alterations in _FAT1_ are selected early during lung cancer evolution
and cause chromosomal instability and whole-genome doubling. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS
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regard to jurisdictional claims in published maps and institutional affiliations. THIS IS A SUMMARY OF: Lu, W.-T. et al. TRACERx analysis identifies a role for _FAT1_ in regulating
chromosomal instability and whole-genome doubling via Hippo signalling. _Nat. Cell Biol_. https://doi.org/10.1038/s41556-024-01558-w (2024). RIGHTS AND PERMISSIONS Reprints and permissions
ABOUT THIS ARTICLE CITE THIS ARTICLE _FAT1_ alterations contribute to chromosomal instability in cancer cells. _Nat Cell Biol_ 27, 12–13 (2025). https://doi.org/10.1038/s41556-024-01559-9
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