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Access through your institution Buy or subscribe Obesity can lead to remodelling of the microvasculature, increasing the risk of organ failure. This remodelling is thought to occur in
response to arterial hypertension. However, Cristina García-Cáceres and colleagues have demonstrated that obesity-induced hypothalamic microvascular remodelling precedes increases in blood
pressure and contributes to arterial hypertension. The researchers showed that leptin signalling, not adiposity, was important for hypothalamic microvascular remodelling. Leptin-deficient
obese mice (_Lep_ob/ob) had normal levels of hypothalamic microvascular density compared with non-obese controls. In addition, treating _Lep_ob/ob mice with exogenous leptin or
overexpressing leptin in non-obese mice led to hypothalamic hypervascularization. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your
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REFERENCES ORIGINAL ARTICLE * Gruber, T. et al. Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension. _Cell Metab._
https://doi.org/10.1016/j.cmet.2021.04.007 (2021) Article PubMed Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Endocrinology
http://www.nature.com/nrendo/ Olivia Tysoe Authors * Olivia Tysoe View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to
Olivia Tysoe. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Tysoe, O. Hypothalamic vascular remodelling in obesity. _Nat Rev Endocrinol_ 17, 382
(2021). https://doi.org/10.1038/s41574-021-00511-3 Download citation * Published: 17 May 2021 * Issue Date: July 2021 * DOI: https://doi.org/10.1038/s41574-021-00511-3 SHARE THIS ARTICLE
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