Although common, post-traumatic headache remains poorly understood and poorly treated. New data have implicated calcitonin gene-related peptide and the trigeminovascular system in this

disorder, opening up new avenues for research into its pathophysiology and treatment. Access through your institution Buy or subscribe This is a preview of subscription content, access via

your institution RELEVANT ARTICLES Open Access articles citing this article. * REPEAT MILD TRAUMATIC BRAIN INJURIES (RMTBI) MODIFY NOCICEPTION AND DISRUPT OREXINERGIC CONNECTIVITY WITHIN THE

DESCENDING PAIN PATHWAY * Jennaya Christensen * , Naomi MacPherson *  … Richelle Mychasiuk _The Journal of Headache and Pain_ Open Access 14 June 2023 * INTERRELATIONS BETWEEN MIGRAINE-LIKE

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* Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Ashina, H. et al. Post-traumatic headache: epidemiology and pathophysiological insights.

_Nat. Rev. Neurol._ 15, 607–617 (2019). Article  Google Scholar  * Bree, D., Stratton, J. & Levy, D. Increased severity of closed head injury or repetitive subconcussive head impacts

enhances post-traumatic headache-like behaviors in a rat model. _Cephalalgia_ 20, 1224–1239 (2020). Article  Google Scholar  * Navratilova, E. et al. CGRP-dependent and independent

mechanisms of acute and persistent post-traumatic headache following mild traumatic brain injury in mice. _Cephalalgia_ 39, 1762–1775 (2019). Article  Google Scholar  * Larsen, E. L. et al.

Acute and preventive pharmacological treatment of post-traumatic headache: a systematic review. _J. Headache Pain_ 20, 98–106 (2019). Article  Google Scholar  * Ashina, H. et al.

Hypersensitivity to calcitonin gene-related peptide in post-traumatic headache. _Ann. Neurol._ https://doi.org/10.1002/ana.25915 (2020). Article  PubMed  Google Scholar  * Hadjikhani, N. et

al. Extra-axial inflammatory signal in parameninges in migraine with visual aura. _Ann Neurol._ 87, 939–949 (2020). Article  Google Scholar  * Ashina, M. et al. Migraine and the

trigeminovascular system- 40 years and counting. _Lancet Neurol._ 18, 1864–1877 (2020). Google Scholar  * Charles, A. & Pozo-Rosich, P. Targeting calcitonin gene-related peptide: a new

era in migraine therapy. _Lancet_ 394, 1765–1774 (2019). Article  Google Scholar  * Hansen, J. M., Hauge, A. W., Olesen, J. & Ashina, M. Calcitonin gene-related peptide triggers

migraine-like attacks in patients with migraine with aura. _Cephalalgia_ 30, 1179–1186 (2010). Article  Google Scholar  * Ashina, H. et al. Efficacy, tolerability, and safety of erenumab for

the preventive treatment of persistent post-traumatic headache attributed to mild traumatic brain injury: an open-label study. _J. Headache Pain_ 21, 62–70 (2020). Article  CAS  Google

Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * 1st Neurology Department, Aeginition Hospital, Medical School, National and Kapodistrian University of Athens,

Athens, Greece Dimos D. Mitsikostas * Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA Michael A. Moskowitz Authors *

Dimos D. Mitsikostas View author publications You can also search for this author inPubMed Google Scholar * Michael A. Moskowitz View author publications You can also search for this author

inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Dimos D. Mitsikostas. ETHICS DECLARATIONS COMPETING INTERESTS D.D.M. has received honoraria and research or travel grants from

Amgen, Allergan, Biogen, Genesis Pharma, Eli Lily, Novartis, Merz, Roche, Specifar, Teva. M.A.M. declares no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS

ARTICLE CITE THIS ARTICLE Mitsikostas, D.D., Moskowitz, M.A. Making headway — a role for CGRP in post-traumatic headache. _Nat Rev Neurol_ 17, 133–134 (2021).

https://doi.org/10.1038/s41582-020-00431-2 Download citation * Published: 16 November 2020 * Issue Date: March 2021 * DOI: https://doi.org/10.1038/s41582-020-00431-2 SHARE THIS ARTICLE

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