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Access through your institution Buy or subscribe A polygenic risk score for rheumatoid arthritis (RA), which was developed using a cohort of identical twins who did not have RA and validated
against a diagnosis of RA using samples from the UK Biobank, was associated with the presence of _Prevotella_ spp. in the gut in the absence of RA, suggesting an association between gut
microbiota and host genotype before disease onset. The association between genes and microbiota was further validated in a cohort of first-degree relatives of patients with RA, in whom
_Prevotella_ spp. were associated with the _HLA-DRB1_ shared epitope and with preclinical arthritis. This is a preview of subscription content, access via your institution ACCESS OPTIONS
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Contact customer support REFERENCES ORIGINAL ARTICLE * Wells, P. M. et al. Associations between gut microbiota and genetic risk for rheumatoid arthritis in the absence of disease: a
cross-sectional study. _Lancet Rheumatol._ 2, E418–E427 (2020) Article Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Rheumatology
http://www.nature.com/nrrheum/ Joanna Clarke Authors * Joanna Clarke View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence
to Joanna Clarke. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Clarke, J. _Prevotella_ species associated with RA-risk genes. _Nat Rev Rheumatol_ 16,
472 (2020). https://doi.org/10.1038/s41584-020-0476-3 Download citation * Published: 17 July 2020 * Issue Date: September 2020 * DOI: https://doi.org/10.1038/s41584-020-0476-3 SHARE THIS
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