Microbiota, metabolism and lupus in mice

Microbiota, metabolism and lupus in mice

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Access through your institution Buy or subscribe Changes in the gut microbiota have previously been associated with systemic lupus erythematosus (SLE) in humans and in mouse models of the disease, as have changes in the metabolism of tryptophan, which requires microbial involvement. However, a causative link between gut microbiota dysbiosis, tryptophan metabolism and autoimmune disease was lacking. In a new study published in _Science Translational Medicine_, researchers demonstrated that dysbiotic gut microbiota from lupus-prone mice can initiate autoimmunity in healthy mice and that this disease trigger can be modified by manipulating tryptophan metabolism. Fecal transfer from B6._Sle1.Sle2.Sle3_ lupus-prone mice to control C57BL/6 mice (which are 95% genetically identical to the lupus-prone mice) caused the control mice to develop autoimmunity, but only when the donor lupus-prone mice showed signs of autoimmune disease. However, co-housing of lupus-prone and control mice reduced autoimmunity in the lupus-prone mice but did not generate full-blown autoimmunity in the control mice, suggesting a mitigating effect of horizontal transfer of microbes. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $29.99 / 30 days cancel any time Learn more Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE * Choi, S.-C. et al. Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice. _Sci. Transl Med._ 12, eaxx2220 (2020) Article  Google Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Rheumatology http://www.nature.com/nrrheum/ Joanna Clarke Authors * Joanna Clarke View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Joanna Clarke. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Clarke, J. Microbiota, metabolism and lupus in mice. _Nat Rev Rheumatol_ 16, 474 (2020). https://doi.org/10.1038/s41584-020-0482-5 Download citation * Published: 23 July 2020 * Issue Date: September 2020 * DOI: https://doi.org/10.1038/s41584-020-0482-5 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative

Access through your institution Buy or subscribe Changes in the gut microbiota have previously been associated with systemic lupus erythematosus (SLE) in humans and in mouse models of the


disease, as have changes in the metabolism of tryptophan, which requires microbial involvement. However, a causative link between gut microbiota dysbiosis, tryptophan metabolism and


autoimmune disease was lacking. In a new study published in _Science Translational Medicine_, researchers demonstrated that dysbiotic gut microbiota from lupus-prone mice can initiate


autoimmunity in healthy mice and that this disease trigger can be modified by manipulating tryptophan metabolism. Fecal transfer from B6._Sle1.Sle2.Sle3_ lupus-prone mice to control C57BL/6


mice (which are 95% genetically identical to the lupus-prone mice) caused the control mice to develop autoimmunity, but only when the donor lupus-prone mice showed signs of autoimmune


disease. However, co-housing of lupus-prone and control mice reduced autoimmunity in the lupus-prone mice but did not generate full-blown autoimmunity in the control mice, suggesting a


mitigating effect of horizontal transfer of microbes. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and


54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $29.99 / 30 days cancel any time Learn more Subscribe to this journal Receive 12 print issues and


online access $209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes


which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE *


Choi, S.-C. et al. Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice. _Sci. Transl Med._ 12, eaxx2220 (2020) Article  Google


Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Rheumatology http://www.nature.com/nrrheum/ Joanna Clarke Authors * Joanna Clarke View author


publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Joanna Clarke. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS


ARTICLE CITE THIS ARTICLE Clarke, J. Microbiota, metabolism and lupus in mice. _Nat Rev Rheumatol_ 16, 474 (2020). https://doi.org/10.1038/s41584-020-0482-5 Download citation * Published: 23


July 2020 * Issue Date: September 2020 * DOI: https://doi.org/10.1038/s41584-020-0482-5 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get


shareable link Sorry, a shareable link is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative