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Access through your institution Buy or subscribe Changes in the gut microbiota have previously been associated with systemic lupus erythematosus (SLE) in humans and in mouse models of the
disease, as have changes in the metabolism of tryptophan, which requires microbial involvement. However, a causative link between gut microbiota dysbiosis, tryptophan metabolism and
autoimmune disease was lacking. In a new study published in _Science Translational Medicine_, researchers demonstrated that dysbiotic gut microbiota from lupus-prone mice can initiate
autoimmunity in healthy mice and that this disease trigger can be modified by manipulating tryptophan metabolism. Fecal transfer from B6._Sle1.Sle2.Sle3_ lupus-prone mice to control C57BL/6
mice (which are 95% genetically identical to the lupus-prone mice) caused the control mice to develop autoimmunity, but only when the donor lupus-prone mice showed signs of autoimmune
disease. However, co-housing of lupus-prone and control mice reduced autoimmunity in the lupus-prone mice but did not generate full-blown autoimmunity in the control mice, suggesting a
mitigating effect of horizontal transfer of microbes. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Access Nature and
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which are calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLE *
Choi, S.-C. et al. Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice. _Sci. Transl Med._ 12, eaxx2220 (2020) Article Google
Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Rheumatology http://www.nature.com/nrrheum/ Joanna Clarke Authors * Joanna Clarke View author
publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Joanna Clarke. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS
ARTICLE CITE THIS ARTICLE Clarke, J. Microbiota, metabolism and lupus in mice. _Nat Rev Rheumatol_ 16, 474 (2020). https://doi.org/10.1038/s41584-020-0482-5 Download citation * Published: 23
July 2020 * Issue Date: September 2020 * DOI: https://doi.org/10.1038/s41584-020-0482-5 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get
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