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We developed a CRISPR-based functional assay for genetic sequence variants found in human disease, probing their effects on cell proliferation, survival, motility and any physiological or
pathological process measurable by fluorescence-activated cell sorting (FACS). The assay accurately assessed variant pathogenicity, drug responsiveness or resistance and mechanistic role in
disease, in vitro and in vivo. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your
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CRISPR–CAS GENOME-EDITING TECHNOLOGY. Article CAS Google Scholar Download references ADDITIONAL INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with regard to jurisdictional
claims in published maps and institutional affiliations. THIS IS A SUMMARY OF: Niu, Y. et al. Multiparametric and accurate functional analysis of genetic sequence variants using
CRISPR-Select. _Nat. Genet_. https://doi.org/10.1038/s41588-022-01224-7 (2022). RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE A versatile functional
assay for genetic variants in human disease. _Nat Genet_ 54, 1778–1779 (2022). https://doi.org/10.1038/s41588-022-01226-5 Download citation * Published: 05 December 2022 * Issue Date:
December 2022 * DOI: https://doi.org/10.1038/s41588-022-01226-5 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a
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