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_Cell_ https://doi.org/10.1016/j.cell.2021.05.032 (2021) Antibodies against viruses are not always protective. In _Cell_, Arase and colleagues identify Abs against SARS-CoV-2 that bind the
N-terminal domain (NTD) of the spike (S) protein and induce an open conformation of the receptor-binding domain (RBD), which results in enhanced binding to the virus receptor ACE2 and
enhanced infectivity. In a screen of Abs isolated from patients with COVID-19, some of the Abs to NTD enhance the binding of S protein to ACE2 to a level higher than that of the D614G mutant
S protein, which is known to have an open RBD conformation. All enhancing Abs bind the same sites (W64, H66, V213 and R214) in the S protein, dock similarly on the NTD and induce the open
RBD state. Enhancing Abs reduce the neutralizing capacity of neutralizing Abs. Patients with COVID-19 have both enhancing and neutralizing Abs, and the difference between enhancing and
neutralizing titers is greater in patients with severe as compared to non-severe disease. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Immunology https://www.nature.com/natimmunol
Ioana Visan Authors * Ioana Visan View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Ioana Visan. RIGHTS AND
PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Visan, I. Enhancing antibodies. _Nat Immunol_ 22, 800 (2021). https://doi.org/10.1038/s41590-021-00973-7 Download
citation * Published: 28 June 2021 * Issue Date: July 2021 * DOI: https://doi.org/10.1038/s41590-021-00973-7 SHARE THIS ARTICLE Anyone you share the following link with will be able to read
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