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New work on DNA polymerase λ highlights its remarkable flexibility. This fits with the generally adaptable nature of the DNA-repair process in which this enzyme is involved—nonhomologous
end-joining—which allows this mechanism to handle diverse types of broken DNA ends in order to restore the duplex structure, albeit with a loss of information at the join. Access through
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calculated during checkout ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES * Zhao, B., Rothenberg, E.,
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ACKNOWLEDGEMENTS M.R.L. is supported by National Interests of Health grants GM118009 and CA100504. AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * University of Southern California, Los
Angeles, CA, USA Michael R. Lieber Authors * Michael R. Lieber View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to
Michael R. Lieber. ETHICS DECLARATIONS COMPETING INTERESTS The author declares no competing interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE
Lieber, M.R. Pol X DNA polymerases contribute to NHEJ flexibility. _Nat Struct Mol Biol_ 30, 5–8 (2023). https://doi.org/10.1038/s41594-022-00904-6 Download citation * Published: 31 December
2022 * Issue Date: January 2023 * DOI: https://doi.org/10.1038/s41594-022-00904-6 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get
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