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In vitro reconstitution of recognition of 80S ribosomes by CCR4–NOT, cryo-electron microscopy (cryoEM), crosslinking mass spectrometry and biochemical characterization reveal that CCR4–NOT
specifically identifies ribosomes stalled during translation elongation. CCR4–NOT occupies the ribosomal exit site (E site) and locks the ribosomal L1 stalk in an open conformation to
enforce the stalled state. Access through your institution Buy or subscribe This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your
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INFORMATION PUBLISHER’S NOTE Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. THIS IS A SUMMARY OF: Absmeier, E. et al.
Specific recognition and ubiquitination of translating ribosomes by mammalian CCR4–NOT. _Nat. Struct. Mol. Biol_. https://doi.org/10.1038/s41594-023-01075-8 (2023). RIGHTS AND PERMISSIONS
Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Mammalian CCR4–NOT binds and ubiquitinates 80S ribosomes to enforce translational stalling. _Nat Struct Mol Biol_ 30, 1254–1255
(2023). https://doi.org/10.1038/s41594-023-01079-4 Download citation * Published: 05 September 2023 * Issue Date: September 2023 * DOI: https://doi.org/10.1038/s41594-023-01079-4 SHARE THIS
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