ABSTRACT Interferon-gamma (IFN-γ) is a key regulator of the development and functions of the immune system. In particular, this cytokine plays a major role in immune defense against

infections by various human pathogens and polymorphisms in the IFN-γ gene, including the transcription regulatory region, and might affect host resistance to infectious agents such as

schistosomes. In this study on the genetics of human schistosomiasis we uncovered three new single nucleotide polymorphisms in the IFN-γ genes. Two polymorphisms are located in the third

intron and the third is in the 3 ′UTR region of this gene: an A to G transition at position +2109 from the transcription start and two G to A transitions at positions +3810 and +5134. In a

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Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS ASSOCIATION BETWEEN INTERLEUKIN 10 (IL-10) POLYMORPHISMS AND LEISHMANIASIS PROGRESSION: A SYSTEMATIC REVIEW AND META-ANALYSIS

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for critical reading of the manuscript. AUTHOR INFORMATION Author notes * S Henri and C Chevillard: C Chevillard and S Henri were supported by fellowships from the Conseil Général PACA and

from the french Ministry of Research and Technologies. AUTHORS AND AFFILIATIONS * INSERM U399, Immunologie et Génétique des Maladies Parasitaires, Faculté de Médecine, 27 bd J. Moulin,

Marseille cedex, 13385, France S Henri, F Stefani, C Eboumbou, A Dessein & C Chevillard * Institut de Médecine Tropicale du Service de Santé des Armées (IMTSSA), Marseille, F-13007,

France D Parzy Authors * S Henri View author publications You can also search for this author inPubMed Google Scholar * F Stefani View author publications You can also search for this author

inPubMed Google Scholar * D Parzy View author publications You can also search for this author inPubMed Google Scholar * C Eboumbou View author publications You can also search for this

author inPubMed Google Scholar * A Dessein View author publications You can also search for this author inPubMed Google Scholar * C Chevillard View author publications You can also search

for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to C Chevillard. ADDITIONAL INFORMATION This work received financial assistance from INSERM, CNRS, WHO (ID096546).

RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Henri, S., Stefani, F., Parzy, D. _et al._ Description of three new polymorphisms in the intronic and

3′UTR regions of the human interferon gamma gene. _Genes Immun_ 3, 1–4 (2002). https://doi.org/10.1038/sj.gene.6363809 Download citation * Received: 20 August 2001 * Revised: 10 September

2001 * Accepted: 10 September 2001 * Published: 21 February 2002 * Issue Date: 01 February 2002 * DOI: https://doi.org/10.1038/sj.gene.6363809 SHARE THIS ARTICLE Anyone you share the

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Nature SharedIt content-sharing initiative KEYWORDS * interferon gamma * polymorphisms * SNPs