ABSTRACT T helper type 2 (TH2)-mediated immune responses are induced after infection with multicellular parasites and can be triggered by a variety of allergens. The mechanisms of induction

and the antigen-presenting cells involved in the activation of TH2 responses remain poorly defined, and the innate immune sensing pathways activated by parasites and allergens are largely

unknown. Basophils are required for the _in vivo_ induction of TH2 responses by protease allergens. Here we show that basophils also function as antigen-presenting cells. We show that

although dendritic cells were dispensable for allergen-induced activation of TH2 responses _in vitro_ and _in vivo_, antigen presentation by basophils was necessary and sufficient for this.

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ADDITIONAL ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support SIMILAR CONTENT BEING VIEWED BY OTHERS BASOPHILS PRIME GROUP 2

INNATE LYMPHOID CELLS FOR NEUROPEPTIDE-MEDIATED INHIBITION Article 17 August 2020 THE KINASE P38Α FUNCTIONS IN DENDRITIC CELLS TO REGULATE TH2-CELL DIFFERENTIATION AND ALLERGIC INFLAMMATION

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Indirect involvement of allergen-captured mast cells in antigen presentation. _Blood_ 111, 1489–1496 (2008). Article  CAS  Google Scholar  Download references ACKNOWLEDGEMENTS We thank I.

Weissman (Stanford University) for H-2k–Bcl-2 mice; K. Bottomly (Yale University) for DO11.10 × 4get transgenic mice; A. Iwasaki (Yale University) for mice and reagents; S. Holley, C.

Annicelli and M. Kotas for technical assistance; and J. Kagan and D. Hargreaves for experimental input. Supported by the US National Institutes of Health (Medical Scientist Training Program

TG2T32GM07205 to C.L.S. and R01 AI46688 and R01 AI055502 to R.M.), the Howard Hughes Medical Institute (R.M.) and the Sandler Program in Asthma Research. AUTHOR INFORMATION AUTHORS AND

AFFILIATIONS * Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA Caroline L Sokol, Ngoc-Quynh Chu, Shuang Yu, 

Simone A Nish & Ruslan Medzhitov * Immunology Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania, USA Terri M Laufer Authors * Caroline L Sokol View author

publications You can also search for this author inPubMed Google Scholar * Ngoc-Quynh Chu View author publications You can also search for this author inPubMed Google Scholar * Shuang Yu

View author publications You can also search for this author inPubMed Google Scholar * Simone A Nish View author publications You can also search for this author inPubMed Google Scholar *

Terri M Laufer View author publications You can also search for this author inPubMed Google Scholar * Ruslan Medzhitov View author publications You can also search for this author inPubMed 

Google Scholar CONTRIBUTIONS C.L.S. and R.M. designed the experiments; C.L.S., N.-Q.C., S.Y. and S.A.N. did the experiments; C.L.S. and R.M. analyzed the data and wrote the manuscript; and

T.M.L. provided CD11c-IABB mice. CORRESPONDING AUTHOR Correspondence to Ruslan Medzhitov. SUPPLEMENTARY INFORMATION SUPPLEMENTARY TEXT AND FIGURES Supplementary Figures 1–4 and Supplementary

Methods (PDF 8178 kb) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Sokol, C., Chu, NQ., Yu, S. _et al._ Basophils function as antigen-presenting

cells for an allergen-induced T helper type 2 response. _Nat Immunol_ 10, 713–720 (2009). https://doi.org/10.1038/ni.1738 Download citation * Received: 17 December 2008 * Accepted: 14 April

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