Mutations have been the driving force behind some of the most important discoveries in immunology, and the growing speed with which they can be found has impelled the use of random

mutagenesis to create new immunological phenotypes in mice. Here we describe how phenotypes are created, detected and ascribed to genetic change. Access through your institution Buy or

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AFFILIATIONS * Xin Du and Yu Xia are in the Department of Genetics, Bruce Beutler, The Scripps Research Institute, La Jolla, California 92037, USA. [email protected], Bruce Beutler, Xin Du 

& Yu Xia Authors * Bruce Beutler View author publications You can also search for this author inPubMed Google Scholar * Xin Du View author publications You can also search for this

author inPubMed Google Scholar * Yu Xia View author publications You can also search for this author inPubMed Google Scholar ETHICS DECLARATIONS COMPETING INTERESTS The authors declare no

competing financial interests. SUPPLEMENTARY INFORMATION SUPPLEMENTARY TABLE 1 (PDF 2680 KB) RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Beutler, B.,

Du, X. & Xia, Y. Precis on forward genetics in mice. _Nat Immunol_ 8, 659–664 (2007). https://doi.org/10.1038/ni0707-659 Download citation * Issue Date: July 2007 * DOI:

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