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Access through your institution Buy or subscribe Epigenetics involves the self-perpetuation of post-translational modifications of DNA, which lead to lasting alterations in chromatin
structure and gene expression. Several recent studies suggest that epigenetic modifications could be involved in the pathophysiology of depression and other psychiatric disorders.
ʟ-acetylcarnitine is currently marketed for the treatment of neuropathic pain and is known to cause analgesia by increasing the expression of metabotropic glutamate receptor 2 (mGluR2)
through an epigenetic mechanism. > ʟ-acetylcarnitine ... has a rapid and long-lasting antidepressant > effect in rodent models of depression This is a preview of subscription content,
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OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Nasca, C. et al. ʟ-acetylcarnitine causes rapid
antidepressant effects through the epigenetic induction of mGlu2 receptors. _Proc. Natl Acad. Sci. USA_ 4 Feb 2013 (doi:10.1073/pnas.1216100110) Article CAS Google Scholar Download
references Authors * Monica Hoyos Flight View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS
ARTICLE CITE THIS ARTICLE Flight, M. Antidepressant epigenetic action. _Nat Rev Neurosci_ 14, 226–227 (2013). https://doi.org/10.1038/nrn3466 Download citation * Published: 27 February 2013
* Issue Date: April 2013 * DOI: https://doi.org/10.1038/nrn3466 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a
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