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Access through your institution Buy or subscribe Chondrodystophic dogs (e.g. Beagles) have disproportionately short limbs relative to their spines, and show signs of intervertebral disc
degeneration by the time they reach 1 year of age. Microarray analysis of discs in different stages of degeneration from chondrodystrophic and nonchondrodystrophic dogs revealed a
downregulation of genes involved in Wnt signalling throughout the degenerative process. The investigators hypothesized that the increased levels of Wnt signalling observed in
chondrodystrophic dogs could be an ineffective attempt to preserve the notochordal phenotype of NP cells. Caveolin-1 regulates Wnt signalling through multiple proposed mechanisms. Decreased
caveolin-1 expression in canine discs with chondrocyte-like cells prompted the investigators to examine intervertebral discs from mice lacking expression of caveolin-1. NP tissue from these
mice showed abnormal structure, with dying cells and a large amount of chondroid-like matrix. “The local changes in biomolecular signalling may also, and probably primarily, affect the
niches of stem cells and their cross-talk with the resident cells within the intervertebral disc,” says author Mariana Tryfonidou. She plans to investigate the effects of caveolin-1 on the
different cell types found in intervertebral discs. This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this
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support ORIGINAL RESEARCH PAPER * Smolders, L. A. _ et al_. Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and
caveolin-1 expression: implications for development of regenerative strategies. _Arthritis Res. Ther._ doi:10.1186/ar4157 Download references Authors * Megan Cully View author publications
You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Cully, M. Altered Wnt signalling in
intervertebral disc degeneration. _Nat Rev Rheumatol_ 9, 136 (2013). https://doi.org/10.1038/nrrheum.2013.22 Download citation * Published: 12 February 2013 * Issue Date: March 2013 * DOI:
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