Circulating tumour cells might not only seed distant organs but also reseed the original cancer site, leading to accelerated tumour growth and decreased survival. A recent study suggests

that radical prostatectomy might reduce the risk of reseeding and subsequent disease progression in patients with metastatic prostate cancer. Access through your institution Buy or subscribe

This is a preview of subscription content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access

$209.00 per year only $17.42 per issue Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are

follow-up of 102 months. _Jpn J. Clin. Oncol._ 36, 789–793 (2006). Article  PubMed  Google Scholar  * Paulson, D. F., Lin, G. H., Hinshaw, W. & Stephani, S. Radical surgery versus

radiotherapy for adenocarcinoma of the prostate. _J. Urol._ 128, 502–504 (1982). Article  CAS  PubMed  Google Scholar  * Penson, D. F. An update on randomized clinical trials in localized

and locoregional prostate cancer. _Urol. Oncol._ 23, 280–288 (2005). Article  PubMed  Google Scholar  * Siegel, R., Naishadham, D. & Jemal, A. Cancer statistics, 2013. _CA Cancer J.

Clin._ 63, 11–30 (2013). PubMed  Google Scholar  * Kim, M. Y. _ et al_. Tumor self-seeding by circulating cancer cells. _Cell_ 139, 1315–1326 (2009). Article  PubMed  PubMed Central  Google

Scholar  * Shao, Y. H. _ et al_. Cancer-specific survival after metastasis following primary radical prostatectomy compared with radiation therapy in prostate cancer patients: results of a

population-based, propensity score–matched analysis. _Eur. Urol._ http://dx.doi.org/10.1016/j.eururo.2013.05.023. * Hoffman, R. M., Stone, S. N., Hunt, W. C., Key, C. R. & Gilliland, F.

D. Effects of misattribution in assigning cause of death on prostate cancer mortality rates. _Ann. Epidemiol._ 13, 450–454 (2003). Article  PubMed  Google Scholar  * Warlick, C., Trock, B.

J., Landis, P., Epstein, J. I. & Carter, H. B. Delayed versus immediate surgical intervention and prostate cancer outcome. _J. Natl Cancer Inst._ 98, 355–357 (2006). Article  PubMed 

Google Scholar  * Comen, E., Norton, L. & Massagué, J. Clinical implications of cancer self-seeding. _Nat. Rev. Clin. Oncol._ 8, 369–377 (2011). Article  PubMed  Google Scholar  *

Aguirre-Ghiso, J. A. On the theory of tumor self-seeding: implications for metastasis progression in humans. _Breast Cancer Res._ 12, 304 (2010). Article  PubMed  PubMed Central  Google

Scholar  Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Department of Radiation Oncology, Virginia Commonwealth University, 401 College Street, P. O. Box 980058, Richmond,

23298-0058, VA, USA Drew Moghanaki & Mitchell S. Anscher Authors * Drew Moghanaki View author publications You can also search for this author inPubMed Google Scholar * Mitchell S.

Anscher View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Mitchell S. Anscher. ETHICS DECLARATIONS COMPETING

INTERESTS The authors declare no competing financial interests. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Moghanaki, D., Anscher, M. Should men

with metastases undergo radical prostatectomy?. _Nat Rev Urol_ 10, 501–502 (2013). https://doi.org/10.1038/nrurol.2013.154 Download citation * Published: 16 July 2013 * Issue Date: September

2013 * DOI: https://doi.org/10.1038/nrurol.2013.154 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link

is not currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative