ABSTRACT New ambuic acid derivatives, pestallic acids R–V (1−5), together with ambuic acid (6), were isolated from the endophytic fungus _Pestalotiopsis trachicarpicola_ SC-J551 derived from

the fern _Blechnum orientale_ L., of which compound 2, being racemic, was separated to two optically pure enantiomers (+)-2 and (−)-2. The structures including absolute configurations of

these new compounds were elucidated by extensive spectroscopic analysis and theoretical simulations of their ECD spectra and 13C NMR chemical shifts. Compounds 1 and 3 exhibited cytotoxicity

against human carcinoma A549, HeLa, HepG2, and MCF-7 cells (IC50: 3.6–12.5 μM) and compound 3 was also active against _Staphylococcus aureus_ and MRSA (MIC = 20 μg ml−1). Compound (±)-2

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ANTIBACTERIAL ANGUCYCLINONE AND Α-PYRONE DERIVATIVES FROM DESERT-DERIVED _NOCARDIOPSIS DASSONVILLEI_ HDN 154151 Article 25 April 2022 ANTIMICROBIAL POLYKETIDES FROM MAGELLAN

SEAMOUNT-DERIVED FUNGUS _TALAROMYCES SCORTEUS_ AS-242 Article 17 October 2023 DISCOVERY, TOTAL SYNTHESES AND POTENT ANTI-INFLAMMATORY ACTIVITY OF PYRROLINONE-FUSED BENZOAZEPINE ALKALOIDS

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2022;202:113295. Article  CAS  PubMed  Google Scholar  Download references ACKNOWLEDGEMENTS We thank Mr. Yunfei Yuan, South China Botanical Garden, Chinese Academy of Sciences, for NMR

spectroscopic measurements and Ms. Aijun Sun, South China Sea Institute of Oceanology, Chinese Academy of Sciences, for HRESIMS measurements. This work was supported by NSFC grants (Nos.

82073732 and 81872773). Electronic supplementary information (ESI) available on The Journal of Antibiotics website (http://www.nature.com/ja). Computational details, NMR spectra and HR-ESIMS

of 1‒5, and HPLC chromatograms of 1‒6 (PDF). AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese

Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou, 510650, People’s Republic of China Fanyu Dong, Zhiming Jiang, Ping Wu, Fangfang Duan, Jinghua Xue, Haibo Tan & Xiaoyi

Wei * School of Life Sciences, University of Chinese Academy of Sciences, Yuquanlu 19A, Beijing, 100049, People’s Republic of China Fanyu Dong & Zhiming Jiang Authors * Fanyu Dong View

author publications You can also search for this author inPubMed Google Scholar * Zhiming Jiang View author publications You can also search for this author inPubMed Google Scholar * Ping Wu

View author publications You can also search for this author inPubMed Google Scholar * Fangfang Duan View author publications You can also search for this author inPubMed Google Scholar *

Jinghua Xue View author publications You can also search for this author inPubMed Google Scholar * Haibo Tan View author publications You can also search for this author inPubMed Google

Scholar * Xiaoyi Wei View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHORS Correspondence to Ping Wu or Xiaoyi Wei. ETHICS DECLARATIONS

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acid congeners from endophytic fungus _Pestalotiopsis trachicarpicola_ SC-J551. _J Antibiot_ 77, 21–29 (2024). https://doi.org/10.1038/s41429-023-00674-3 Download citation * Received: 02

July 2023 * Revised: 10 October 2023 * Accepted: 26 October 2023 * Published: 13 November 2023 * Issue Date: January 2024 * DOI: https://doi.org/10.1038/s41429-023-00674-3 SHARE THIS ARTICLE

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