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Access through your institution Buy or subscribe Tumour-infiltrating B cells have been detected in different solid tumour types, but their role in cancer remains unclear. Now, the findings
of three independent studies published simultaneously in _Nature_ indicate that B cells and tertiary lymphoid structures (TLSs) are key determinants of a response to immune-checkpoint
inhibition (ICI). The expression of a B cell signature was assessed in cutaneous melanoma samples from The Cancer Genome Atlas. Among three distinct melanoma immune classes identified,
cluster C was associated with the highest expression of B cell genes and the most favourable overall survival (OS; _P_ < 0.0001 and _P_ = 0.068, respectively, both versus cluster A). “Our
observations suggest that responses to ICIs require the orchestrated contribution and organization of many cell types in TLSs,” summarizes lead investigator Jennifer Wargo. This is a
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* Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support REFERENCES ORIGINAL ARTICLES * Helmink, B. A. et al. B cells and tertiary lymphoid structures
promote immunotherapy response. _Nature_ 577, 549–555 (2020) Article CAS Google Scholar * Cabrita, R. et al. Tertiary lymphoid structures improve immunotherapy and survival in melanoma.
_Nature_ 577, 561–565 (2020) Article CAS Google Scholar * Petitprez, F. et al. B cells are associated with survival and immunotherapy response in sarcoma. _Nature_ 577, 556–560 (2020)
Article CAS Google Scholar Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Nature Reviews Clinical Oncology http://www.nature.com/nrclinonc Diana Romero Authors * Diana
Romero View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHOR Correspondence to Diana Romero. RIGHTS AND PERMISSIONS Reprints and
permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Romero, D. B cells and TLSs facilitate a response to ICI. _Nat Rev Clin Oncol_ 17, 195 (2020). https://doi.org/10.1038/s41571-020-0338-6
Download citation * Published: 05 February 2020 * Issue Date: April 2020 * DOI: https://doi.org/10.1038/s41571-020-0338-6 SHARE THIS ARTICLE Anyone you share the following link with will be
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