Strong multidisciplinary support and political commitment have helped Spain become one of the countries most likely to eliminate hepatitis C. In this Comment, we set out six key elements of

the Spanish elimination effort that can serve as a model elsewhere and the remaining barriers to overcome. Access through your institution Buy or subscribe This is a preview of subscription

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countries: an updated analysis. _Liver Int._ 41, 456–463 (2021). Article  PubMed  Google Scholar  * Ministry of Health, Social Services and Equality. Strategic Plan for Tackling Hepatitis C

in the Spanish National Health System (Ministry of Health, Social Services and Equality, 2015). * Ministry of Health, Social Services and Equality. Guía de Cribado de la infección por el VHC

[Spanish] (Ministry of Health, Social Services and Equality, 2020). * Crespo, J. et al. A call for the comprehensive diagnosis of viral hepatitis as a key step towards its elimination.

_Liver Int._ 43, 1145–1147 (2023). Article  PubMed  Google Scholar  * Calleja, J. L. et al. Ten steps to eliminating hepatitis C in hospitals. _Nat. Rev. Gastroenterol. Hepatol._ 19, 481–483

(2022). Article  PubMed  Google Scholar  * Cuadrado, A. et al. Microenvironment eradication of hepatitis C: a novel treatment paradigm. _Am. J. Gastroenterol._ 113, 1639–1648 (2018).

Article  PubMed  Google Scholar  * Llaneras, J. et al. OS052 - clinical impact and cost-effectiveness of hepatitis C testing in an emergency department in Barcelona, Spain. _J. Hepatol._ 77,

S44 (2022). Article  Google Scholar  * Politi, J. et al. Favorable impact in hepatitis C-related mortality following free access to direct-acting antivirals in Spain. _Hepatology_ 75,

1247–1256 (2022). Article  CAS  PubMed  Google Scholar  * World Health Organization. Global health sector strategies on, respectively, HIV, viral hepatitis and sexually transmitted

infections for the period 2022-2030 (WHO, 2022). * World Health Organization. Criteria for validation of elimination of viral hepatitis B and C: report of 7 country pilots (WHO, 2022).

Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Gastroenterology and Hepatology Department, Marqués de Valdecilla University Hospital, Santander, Spain Javier Crespo & 

Joaquín Cabezas * Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL), Marqués de Valdecilla University Hospital, Santander, Spain Javier Crespo

 & Joaquín Cabezas * School of Medicine, University of Cantabria, Santander, Spain Javier Crespo * Gastroenterology and Hepatology Department, Puerta de Hierro University Hospital,

Madrid, Spain José Luis Calleja * Puerta de Hierro Majadahonda Research Institute (IDIPHIM), Madrid, Spain José Luis Calleja * Autonomous University of Madrid, Madrid, Spain José Luis

Calleja * Liver Unit, Hospital Universitario Valle Hebrón, Barcelona, Spain María Buti * CIBER del Instituto Carlos III, Barcelona, Spain María Buti * CUNY Graduate School of Public Health

and Health Policy (CUNY SPH), New York, NY, USA Jeffrey V. Lazarus * Barcelona Institute of Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain Jeffrey V.

Lazarus Authors * Javier Crespo View author publications You can also search for this author inPubMed Google Scholar * Joaquín Cabezas View author publications You can also search for this

author inPubMed Google Scholar * José Luis Calleja View author publications You can also search for this author inPubMed Google Scholar * María Buti View author publications You can also

search for this author inPubMed Google Scholar * Jeffrey V. Lazarus View author publications You can also search for this author inPubMed Google Scholar CORRESPONDING AUTHORS Correspondence

to Javier Crespo or Jeffrey V. Lazarus. ETHICS DECLARATIONS COMPETING INTERESTS J. Crespo has been a consultant and/or speaker and/or participated in sponsored clinical trials and/or

received grants and research support from Gilead Sciences, AbbVie, MSD, Shionogi, Intercept Pharmaceuticals, Janssen Pharmaceuticals Inc., Celgene and Alexion, outside of the submitted work.

He is also a member of the Scientific Committee of the Strategic Plan for the Management of Hepatitis C of the Spanish National Health System. J. Cabezas declares lecture fees from, grants

from and advisory board participation for Gilead and AbbVie, outside of the submitted work. J.L.C. declares consultant and lectures fees from Gilead Sciences, AbbVie, MSD and Roche, outside

of the submitted work. M.B. declares speaker fees from and advisory board participation for Gilead, AbbVie and Janssen and a grant from Gilead, outside of the submitted work. J.V.L.

acknowledges grants and speaker fees from AbbVie, Gilead Sciences, MSD and Roche Diagnostics to his institution, speaker fees from Intercept, Janssen, Novo Nordisk and ViiV and consulting

fees from Novavax, outside of the submitted work. He also acknowledges support to ISGlobal from the grant CEX2018-000806-S funded by MCIN/AEI/10.13039/501100011033 and the ‘Generalitat de

Catalunya’ through the CERCA Program, outside of the submitted work. RIGHTS AND PERMISSIONS Reprints and permissions ABOUT THIS ARTICLE CITE THIS ARTICLE Crespo, J., Cabezas, J., Calleja,

J.L. _et al._ The path to successful hepatitis C elimination in Spain. _Nat Rev Gastroenterol Hepatol_ 20, 689–690 (2023). https://doi.org/10.1038/s41575-023-00813-z Download citation *

Published: 27 July 2023 * Issue Date: November 2023 * DOI: https://doi.org/10.1038/s41575-023-00813-z SHARE THIS ARTICLE Anyone you share the following link with will be able to read this

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