Play all audios:
Access through your institution Buy or subscribe RNAi-based therapeutics harness an endogenous cellular regulatory mechanism in which small dsRNA molecules, or siRNAs, bind to and mediate
the destruction of specific mRNA molecules, preventing their translation into protein. Despite its great potential, moving siRNA forward into the clinic is beset by problems with siRNA
stability and _in vivo_ delivery. Current siRNA-based drugs in clinical development rely on direct delivery to the diseased tissue (by injection, for example). Until now, few studies have
reported successful systemic siRNA delivery even in rodent models, and strategies to achieve this are highly sought after. In this study, two collaborating groups targeted a clinically
relevant gene, apolipoprotein B (_APOB_), in a non-human primate using systemically delivered siRNA. siRNA can target molecules that conventional therapeutics cannot reach. One such target
is APOB, a component of low-density lipoprotein (LDL), which is involved in cholesterol transport and metabolism, and is linked with various coronary diseases. Conventional drugs are
available, but suffer from variable response and delayed efficacy; new strategies to reduce LDL are therefore in demand, making APOB an important target. This is a preview of subscription
content, access via your institution ACCESS OPTIONS Access through your institution Subscribe to this journal Receive 12 print issues and online access $209.00 per year only $17.42 per issue
Learn more Buy this article * Purchase on SpringerLink * Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout ADDITIONAL
ACCESS OPTIONS: * Log in * Learn about institutional subscriptions * Read our FAQs * Contact customer support ORIGINAL RESEARCH PAPER * Zimmerman, T. S. et al. RNAi-mediated gene silencing
in non-human primates. _Nature_ 26 March 2006 (doi: 10.1038/nature04688). Download references AUTHOR INFORMATION AUTHORS AND AFFILIATIONS * Locum Associate Editor, Nature Reviews Drug
Discovery, Katherine Whalley Authors * Katherine Whalley View author publications You can also search for this author inPubMed Google Scholar RIGHTS AND PERMISSIONS Reprints and permissions
ABOUT THIS ARTICLE CITE THIS ARTICLE Whalley, K. Breakthrough for systemic RNAi. _Nat Rev Genet_ 7, 331 (2006). https://doi.org/10.1038/nrg1866 Download citation * Issue Date: 01 May 2006 *
DOI: https://doi.org/10.1038/nrg1866 SHARE THIS ARTICLE Anyone you share the following link with will be able to read this content: Get shareable link Sorry, a shareable link is not
currently available for this article. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative